TY - JOUR T1 -中央位置肺癌和隐匿性结节病的风险:客观评价肿瘤中心的多个定义专用成像软件JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02220 -2018欧元六世- 53 - 5 SP - 1802220 AU -卡萨尔,罗伯特·f·AU - Sepesi,鲍里斯•AU - Sagar Ala-Eddin s . AU - Tschirren Juerg盟——陈,风骚女子非盟-李,梁AU -阳光明媚,Jennifer AU - Williams, Joyce AU - Grosu, Horiana B. AU - Eapen, George A. AU - Jimenez, Carlos A. AU - Ost，目前的指南推荐中央位放射学分期T1N0M0非小细胞肺癌(NSCLC)患者的侵袭性纵隔分期。缺乏中央肿瘤的具体定义导致了指南之间的差异和实践模式的异质性。方法我们的目的是研究肿瘤中心性的具体定义及其与隐匿性淋巴结疾病的关系。来自临床(c) T1N0M0非小细胞肺癌患者的术前胸部计算机断层扫描使用专用软件系统进行处理，该系统按照垂直和同心线将肺部分为三分之一。该软件根据肿瘤的中心位置和最中间的方面，准确地将肿瘤分配给特定的第三种类型，创建8种可能的中心肿瘤定义。结果共纳入607例患者。手术治疗596例肿瘤(98%)。总体病理(p) N疾病为:N0 504 (83%)， N1 56 (9%)， N2 47(8%)，无N3。无论肿瘤位置如何，N2疾病的流行率都相对较低。 Central tumours were associated with upstaging from cN0 to any N (pN1/pN2). Two definitions were associated with upstaging to any N: concentric lines, inner one-third, centre of the tumour (OR 3.91, 95% CI 1.85–8.26; p<0.001) and concentric lines, inner two-thirds, most medial aspect of the tumour (OR 1.91, 95% CI 1.23–2.97; p=0.004).Conclusions We objectively identified two specific definitions of central tumours. While the rate of occult mediastinal disease was relatively low regardless of tumour location, central tumours were associated with upstaging from cN0 to any N.In T1N0M0 nonsmall cell lung cancer, the prevalence of occult mediastinal disease is low regardless of tumour location. However, centrally located tumours are at risk of upstaging to any N. Here, two specific definitions of central tumours are identified. http://ow.ly/pqa130nIokW ER -