@Article {cho1802203，作者= {cho，peter s.p.和fletcher，hannah V.和特纳，理查德D.和jolley，Caroline〜J。和嘶嘶声，Intrinder s.}，标题= {慢性难治性咳嗽中受损咳嗽抑制}，体积= {53}，number = {5}，Elocation-Id = {1802203}，年= {2019}，Doi = {10.101183/ 13993003.02203-2018}，出版商= {欧洲呼吸学社会188bet官网地址}，摘要= {慢性咳嗽中的个体功能脑成像表明，与自愿咳嗽抑制相关的皮质区域的激活减少。关于慢性咳嗽患者抑制咳嗽的能力很少。本研究旨在比较在与健康对照中的慢性耐火咳嗽的参与者中吸入辣椒素挑战中自愿抑制咳嗽的能力。此外，本研究旨在评估辣椒素攻击试验的可重复性与自愿咳嗽抑制。慢性耐火咳嗽和健康对照的帕尔酸癌在试图抑制其咳嗽反应的同时进行吸入辣椒素攻击。5天后，进行常规辣椒素攻击试验，没有咳嗽抑制尝试，或者在咳嗽抑制试图试验的重复试验。通过插值计算引出一个，两和五个咳嗽所需的阈值辣椒素浓度。目标24小时咳嗽频率在慢性耐火咳嗽中衡量。医疗控制能够抑制慢性耐火咳嗽的参与者的辣椒素诱发的咳嗽。几何平均值{\ textpm} SD辣椒素剂量阈值（CS5）和没有（C5）〜抑制尝试是254.40 {\ textpm} 3.78与45.89 {\ textpm} 3.95 {\ textmu} mol {\ texthiodccentered} l-1，分别在健康控制（P = 0.033）和3.34 {\ textpm} 5.04与3.86 {\ textpm} 5.13 {\ textmu} mol {\ textmu} mol {\ texthiodcentered} l-1中，在慢性耐火咳嗽的参与者中（p =0.922）。 Capsaicin dose thresholds for triggering five coughs with self-attempted cough suppression were significantly lower in participants with chronic refractory cough than in healthy controls; geometric mean{\textpm}sd 4.94{\textpm}4.43 versus 261.10{\textpm}4.34 {\textmu}mol{\textperiodcentered}L-1, respectively; mean difference (95\% CI) 5.72 (4.54{\textendash}6.91) doubling doses (p\<0.001). Repeatability of cough suppression test in both patients and healthy controls was high; intraclass correlation coefficients of log(CS5) values 0.81 and 0.87, respectively. CS5 was associated with objective cough frequency (ρ=-0.514, p=0.029).Participants with chronic refractory cough were less able to voluntarily suppress capsaicin-evoked cough compared to healthy controls. This may have important implications for the pathophysiology and treatment of chronic cough.Individuals with chronic refractory cough (CRC) are less able to suppress cough during a capsaicin cough suppression test (CST). The CST is repeatable, associated with objective cough frequency and can distinguish patients with CRC from healthy subjects. http://ow.ly/S8Ki30nSaio}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/53/5/1802203}, eprint = {//www.qdcxjkg.com/content/53/5/1802203.full.pdf}, journal = {European Respiratory Journal} }