TY - T1的调和discrepanc的必要ies between two different reference equations for combined single-breath D_LNO–D_LCO in systemic sclerosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02109-2018 VL - 53 IS - 4 SP - 1802109 AU - Radtke, Thomas AU - Hua-Huy, Thông AU - Dressel, Holger AU - Dinh-Xuan, Anh Tuan Y1 - 2019/04/01 UR - //www.qdcxjkg.com/content/53/4/1802109.abstract N2 - Systemic sclerosis (SSc) is a chronic disease of the connective tissue with an estimated prevalence of 5.8 per 100 000 in a multiethnic population living in Europe [1]. The disease mechanisms are highly complex, affecting multiple organs, including the pulmonary system. Severe pulmonary complications include SSc-associated interstitial lung disease (ILD) and pulmonary hypertension (PH), which are also associated with premature mortality [2, 3]. Early diagnosis and monitoring of pulmonary complications by spirometry, body plethysmography and pulmonary diffusing capacity are critical to lung health in SSc patients [4, 5].This study confirms clinically relevant differences between reference equations for nitric oxide pulmonary diffusing capacity (DLNO) in systemic sclerosis. Future work on DLNO reference equations is required to improve the validity of DLNO outcomes. http://ow.ly/NnA030nx1vGWe kindly thank Julia Braun and Sarah Haile (biostatisticians at the University of Zurich, Zurich, Switzerland) for their support with regard to statistical analyses and data interpretation. ER -