TY -的T1 -期间肺血液动力学exercise – research network (PEX-NET) ERS Clinical Research Collaboration: investigating the prognostic relevance of exercise haemodynamics JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00458-2019 VL - 53 IS - 4 SP - 1900458 AU - Kovacs, Gabor AU - Herve, Philippe AU - Olschewski, Horst A2 - , Y1 - 2019/04/01 UR - //www.qdcxjkg.com/content/53/4/1900458.abstract N2 - An elevation of mean pulmonary arterial pressure (PAP) at rest represents a severe medical condition that is independently associated with increased mortality [1–3]. In subjects with normal PAP at rest, an abnormal increase during exercise in relation to the increase in pulmonary arterial blood flow has been proposed as a condition termed “exercise pulmonary hypertension” (exercise PH) [4]. Currently available data support a definition for exercise PH as an increase in the mean PAP to >30 mmHg combined with an increase in total pulmonary resistance to >3 Wood Units during maximal exercise [5]. Exercise PH may represent an early stage of pulmonary vascular disease and other pathological mechanisms in the heart and/or in the lungs. All these mechanisms may lead to dyspnoea on exertion, which is one of the most worrying symptoms in respiratory medicine.PEX-NET is likely to provide answers regarding the prognostic relevance of pulmonary haemodynamics during exercise and will stimulate further research on the underlying pathophysiology, diagnosis and treatment of exercise pulmonary hypertension http://ow.ly/VThP30o2Anl ER -