区慧、周秀华、区罗、曾秀华、区高、吴文伟、吴文华、区金、陈文华、马太福音电视TI -呼出空气分散在高速流鼻插管治疗< em >和< / em > CPAP通过< / em > < em >不同面具援助- 10.1183/13993003.02339 -2018 DP - 2019年4月01 TA -欧洲呼吸杂志》第六PG - 1802339 - 53年IP - 4 4099 - //www.qdcxjkg.com/content/53/4/1802339.short 4100//www.qdcxjkg.com/content/53/4/1802339.full SO - Eur Respir J2019 Apr 01;高流量鼻插管(HFNC)是一种新兴的治疗呼吸衰竭的方法，但治疗过程中呼出的空气弥散程度尚不清楚。我们在隔离室的人类患者模拟器(HPS)上检测了HFNC治疗与持续气道正压(CPAP)治疗期间呼出的空气弥散情况，换气次数为16次·h - 1。方法编制HPS程序，代表不同程度的肺损伤。CPAP以5-20 cmH2O通过鼻枕(Respironics Nuance Pro Gel或ResMed Swift FX)或口鼻口罩(ResMed Quattro Air)进行。HFNC加湿至37°C，以10-60 L·min−1的温度送入HPS。呼出气流用肺内烟雾作标记，用激光光片显示。正常呼出的空气浓度是由烟雾粒子散射的光估计的。显著暴露被定义为≥20%正常化烟雾浓度。Results In the normal lung condition, mean±sd exhaled air dispersion, along the sagittal plane, increased from 186±34 to 264±27 mm and from 207±11 to 332±34 mm when CPAP was increased from 5 to 20 cmH2O via Respironics and ResMed nasal pillows, respectively. Leakage from the oronasal mask was negligible. Mean±sd exhaled air distances increased from 65±15 to 172±33 mm when HFNC was increased from 10 to 60 L·min−1. Air leakage to 620 mm occurred laterally when HFNC and the interface tube became loose.Conclusion Exhaled air dispersion during HFNC and CPAP via different interfaces is limited provided there is good mask interface fitting.Exhaled air dispersion from high-flow nasal cannula (HFNC) and CPAP is limited provided there is good mask interface fitting. However, exhaled air leakage to 620 mm laterally occurs when the connection between HFNC and the interface tube becomes loose. http://ow.ly/lqEF30nqjq6