A Hui, David S. A Chow, Benny K. A Lo, Thomas %A Tsang, Owen T.Y. %A Ko, Fanny W. A Ng, Susanna S. A Gin, Tony %A Chan, Matthew tv . T在高流量鼻插管治疗中呼出空气扩散与CPAP通过高流量鼻导管(HFNC)是一种新兴的治疗呼吸衰竭的方法，但治疗期间呼出的空气弥散程度尚不清楚。我们在隔离室的人类患者模拟器(HPS)上检测了HFNC治疗与持续气道正压(CPAP)治疗期间呼出的空气弥散情况，换气次数为16次·h - 1。方法编制HPS程序，代表不同程度的肺损伤。CPAP以5-20 cmH2O通过鼻枕(Respironics Nuance Pro Gel或ResMed Swift FX)或口鼻口罩(ResMed Quattro Air)进行。HFNC加湿至37°C，以10-60 L·min−1的温度送入HPS。呼出气流用肺内烟雾作标记，用激光光片显示。正常呼出的空气浓度是由烟雾粒子散射的光估计的。显著暴露被定义为≥20%正常化烟雾浓度。结果正常肺情况下，经呼吸科和ResMed鼻枕CPAP从5 cmH2O增加到20 cmH2O时，平均±sd沿矢状面呼气弥散由186±34 mm增加到264±27 mm，由207±11 mm增加到332±34 mm。口鼻面罩的渗漏可以忽略不计。当HFNC从10 L·min−1增加到60 L·min−1时，平均±sd呼出空气距离从65±15增加到172±33 mm。 Air leakage to 620 mm occurred laterally when HFNC and the interface tube became loose.Conclusion Exhaled air dispersion during HFNC and CPAP via different interfaces is limited provided there is good mask interface fitting.Exhaled air dispersion from high-flow nasal cannula (HFNC) and CPAP is limited provided there is good mask interface fitting. However, exhaled air leakage to 620 mm laterally occurs when the connection between HFNC and the interface tube becomes loose. http://ow.ly/lqEF30nqjq6 %U //www.qdcxjkg.com/content/erj/53/4/1802339.full.pdf