TY - T1的新生儿dna甲基化的童年lung function, and the risks of asthma and COPD across the life course JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01795-2018 VL - 53 IS - 4 SP - 1801795 AU - den Dekker, Herman T. AU - Burrows, Kimberley AU - Felix, Janine F. AU - Salas, Lucas A. AU - Nedeljkovic, Ivana AU - Yao, Jin AU - Rifas-Shiman, Sheryl L. AU - Ruiz-Arenas, Carlos AU - Amin, N. AU - Bustamante, Mariona AU - DeMeo, Dawn L. AU - Henderson, A. John AU - Howe, Caitlin G. AU - Hivert, Marie-France AU - Ikram, M. Arfan AU - de Jongste, Johan C. AU - Lahousse, Lies AU - Mandaviya, Pooja R. AU - van Meurs, Joyce B. AU - Pinart, Mariona AU - Sharp, Gemma C. AU - Stolk, Lisette AU - Uitterlinden, André G. AU - Anto, Josep M. AU - Litonjua, Augusto A. AU - Breton, Carrie V. AU - Brusselle, Guy G. AU - Sunyer, Jordi AU - Smith, George Davey AU - Relton, Caroline L. AU - Jaddoe, Vincent W.V. AU - Duijts, Liesbeth Y1 - 2019/04/01 UR - //www.qdcxjkg.com/content/53/4/1801795.abstract N2 - Rationale We aimed to identify differentially methylated regions (DMRs) in cord blood DNA associated with childhood lung function, asthma and chronic obstructive pulmonary disease (COPD) across the life course.Methods We meta-analysed epigenome-wide data of 1688 children from five cohorts to identify cord blood DMRs and their annotated genes, in relation to forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC) ratio and forced expiratory flow at 75% of FVC at ages 7–13 years. Identified DMRs were explored for associations with childhood asthma, adult lung function and COPD, gene expression and involvement in biological processes.Results We identified 59 DMRs associated with childhood lung function, of which 18 were associated with childhood asthma and nine with COPD in adulthood. Genes annotated to the top 10 identified DMRs were HOXA5, PAOX, LINC00602, ABCA7, PER3, CLCA1, VENTX, NUDT12, PTPRN2 and TCL1A. Differential gene expression in blood was observed for 32 DMRs in childhood and 18 in adulthood. Genes related with 16 identified DMRs were associated with respiratory developmental or pathogenic pathways.Interpretation Our findings suggest that the epigenetic status of the newborn affects respiratory health and disease across the life course.We identified 59 differentially methylated regions in cord blood associated with childhood lung function, of which up to 30% were associated with later-life asthma and COPD. The newborns’ epigenetic status might affect respiratory health later in life. http://ow.ly/Vvkh30nlF5l ER -