在< TY - T1的嗜中性粒细胞胞外陷阱em>ex vivo lung perfusion perfusate predict the clinical outcome of lung transplant recipients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01736-2018 VL - 53 IS - 4 SP - 1801736 AU - Caldarone, Lindsay AU - Mariscal, Andrea AU - Sage, Andrew AU - Khan, Meraj AU - Juvet, Stephen AU - Martinu, Tereza AU - Zamel, Ricardo AU - Cypel, Marcelo AU - Liu, Mingyao AU - Palaniyar, Nades AU - Keshavjee, Shaf Y1 - 2019/04/01 UR - //www.qdcxjkg.com/content/53/4/1801736.abstract N2 - Lung transplantation is lifesaving for patients with end-stage lung diseases. However, a scarcity of donor lungs suitable for transplantation limits the number of procedures that can be performed. Furthermore, major obstacles to successful lung transplantation still exist; primary graft dysfunction (PGD), the leading cause of early morbidity and mortality post-lung transplant, develops in ∼15–30% of recipients [1]. Normothermic ex vivo lung perfusion (EVLP) maintains donor lungs in a physiological state through perfusion and ventilation, so that the lungs can be assessed, treated and accepted for transplantation, thereby increasing the donor pool and alleviating the severe shortage of viable donor lungs [2].Neutrophil extracellular traps (NETs) are detectable in donor ex vivo lung perfusate, and higher levels of NETs in perfusate are associated with worse recipient outcomes after transplant http://ow.ly/r4nM30nvZsK ER -