TY -的T1 -肺弹性反冲和通风heterogeneity of diffusion-dependent airways in older people with asthma and fixed airflow obstruction JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01028-2018 VL - 53 IS - 3 SP - 1801028 AU - Tonga, Katrina O. AU - Berend, Norbert AU - Thamrin, Cindy AU - Farah, Claude S. AU - Jetmalani, Kanika AU - Chapman, David G. AU - King, Gregory G. Y1 - 2019/03/01 UR - //www.qdcxjkg.com/content/53/3/1801028.abstract N2 - Small airways are abnormal in asthma [1]. One measurement of small airway function is Sacin, derived from the multiple-breath nitrogen washout (MBNW) test. Sacin reflects ventilation heterogeneity in diffusion-dependent airways, and is correlated with airway hyperresponsiveness [2] and asthma control [3]. Theoretically, heterogeneity of diffusion-dependent ventilation can arise due to the heterogeneity of cross-sectional areas of airway openings in terminal airways and the acini [4]. Therefore, Sacin may be affected by structural changes in those airways. The elastic properties of the lung may also affect Sacin, as the phase III slope, a marker of ventilation heterogeneity derived from the single-breath nitrogen washout, correlates with lung compliance in explanted lungs of smokers and in healthy lungs [5].Loss of lung elastic recoil is associated with increased ventilation heterogeneity in diffusion-dependent airways in older nonsmokers with asthma and fixed airflow obstruction http://ow.ly/g2Sk30nbVXv ER -