PT -期刊文章盟Crombag劳伦斯M.M.盟——注定,克利斯朵夫盟——Stigt乔斯a . AU - Tournoy,库尔特·g . AU - Schuurbiers,奥尔加C.J.盟——Ninaber Maarten k . AU - Buikhuisen Wieneke a . AU - Hashemi赛义德硕士非盟- Bonta,彼得。非盟- Korevaar,丹尼尔·a . AU - AnnemaJouke t TI -系统并结合endosonographic肺癌的分期研究(得分)援助- 10.1183/13993003.00800 -2018 DP - 2019年2月01 TA -欧洲呼吸杂志》第六PG - 1800800 - 53年的IP - 2 4099 - //www.qdcxjkg.com/content/53/2/1800800.short 4100 - //www.qdcxjkg.com/content/53/2/1800800.full所以欧元和J2019 2月01; 53 AB - Guidelines recommend endosonography for mediastinal nodal staging in patients with resectable nonsmall cell lung cancer (NSCLC). We hypothesise that a systematic endobronchial ultrasound (EBUS) evaluation combined with an oesophageal investigation using the same EBUS bronchoscope (EUS-B) improves mediastinal nodal staging versus the current practice of targeted positron emission tomography (PET)-computed tomography (CT)-guided EBUS staging alone.A prospective, multicentre, international study (NCT02014324) was conducted in consecutive patients with (suspected) resectable NSCLC. After PET-CT, patients underwent systematic EBUS and EUS-B. Node(s) suspicious on CT, PET, EBUS and/or EUS-B imaging and station 4R, 4L and 7 (short axis ≥8 mm) were sampled. For patients without N2/N3 disease determined on endosonography, surgical-pathological staging was the reference standard.229 patients were included in this study. The prevalence of N2/N3 disease was 103 out of 229 patients (45%). A PET-CT-guided targeted approach by EBUS identified 75 patients with N2/N3 disease (sensitivity 73%, 95% CI 63–81%; negative predictive value (NPV) 81%, 95% CI 74–87%). Four additional patients with N2/N3 disease were found by systematic EBUS (sensitivity 77%, 95% CI 67–84%; NPV 84%, 95% CI 76–89%) and five more by EUS-B (84 patients total; sensitivity 82%, 95% CI 72–88%; NPV 87%, 95% CI 80–91%). Additional clinical relevant staging information was obtained in 23 out of 229 patients (10%).Systematic EBUS followed by EUS-B increased sensitivity for the detection of N2/N3 disease by 9% compared to PET-CT-targeted EBUS alone.In lung cancer patients, a systematic endobronchial ultrasound (EBUS) combined with an oesophageal investigation using the same EBUS bronchoscope (EUS-B) increases the sensitivity for mediastinal nodal staging by 9% compared to a targeted EBUS procedure http://ow.ly/aPqF30mJ15q