A Crombag, Laurence M.M. A Dooms, Christophe A Stigt, Jos A %A Tournoy, Kurt G. %A Schuurbiers, Olga C.J. A Ninaber, Maarten K. %A Buikhuisen, Wieneke A. A Hashemi, Sayed M.S. %A Bonta, Peter I. %A Korevaar, Daniël A. %A Annema，Jouke T % T系统并结合endosonographic肺癌的分期研究(得分)% D J 2019% R 10.1183/13993003.00800 -2018%欧洲呼吸杂志2% % P 1800800 V % 53% N X指南建议endosonography纵隔淋巴结分期可切除的患者nonsmall细胞性肺癌(NSCLC)。我们假设系统支气管超声(EBUS)评估结合使用同一EBUS支气管镜(EUS-B)进行的食管检查，与目前单独使用靶向正电子发射断层扫描(PET)-计算机断层扫描(CT)引导的EBUS分期相比，可以改善纵隔淋巴结分期。一项前瞻性、多中心、国际研究(NCT02014324)对连续(怀疑)可切除的NSCLC患者进行了研究。PET-CT后，患者接受系统EBUS和EUS-B检查。取CT、PET、EBUS和/或EUS-B显像可疑淋巴结，4R、4L和7(短轴≥8 mm)站。对于经超声诊断无N2/N3病变的患者，手术病理分期为参考标准。229例患者纳入本研究。229名患者中有103人(45%)患有N2/N3疾病。pet - ct引导的EBUS靶向方法确定了75例N2/N3疾病患者(敏感性73%，95% CI 63-81%;阴性预测值(NPV) 81%， 95% CI 74-87%)。通过系统EBUS检测发现另外4例N2/N3疾病患者(敏感性77%，95% CI 67-84%; NPV 84%, 95% CI 76–89%) and five more by EUS-B (84 patients total; sensitivity 82%, 95% CI 72–88%; NPV 87%, 95% CI 80–91%). Additional clinical relevant staging information was obtained in 23 out of 229 patients (10%).Systematic EBUS followed by EUS-B increased sensitivity for the detection of N2/N3 disease by 9% compared to PET-CT-targeted EBUS alone.In lung cancer patients, a systematic endobronchial ultrasound (EBUS) combined with an oesophageal investigation using the same EBUS bronchoscope (EUS-B) increases the sensitivity for mediastinal nodal staging by 9% compared to a targeted EBUS procedure http://ow.ly/aPqF30mJ15q %U //www.qdcxjkg.com/content/erj/53/2/1800800.full.pdf