TY - JOUR T1 -高海拔地区COPD患病率高:家庭空气污染是否起作用?摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.01193 -2018欧元六世- 53 - 2 SP - 1801193 AU Brakema Evelyn a . AU - Tabyshova Aizhamal盟——Kasteleyn Marise J . AU - Molendijk,伊芙琳AU -范德Kleij Rianne M.J.J. AU - van Boven工作F.M.盟——Emilov Berik语盟——Akmatalieva Meerim AU - Mademilov,玛亚盟——Numans Mattijs e . AU -威廉姆斯,西安非盟- Sooronbaev Talant AU -通知,Niels H. Y1 - 2019/02/01 UR - //www.qdcxjkg.com/content/53/2/1801193.abstract N2 -比较不同海拔地区慢性阻塞性肺疾病(COPD)患病率的研究报告了相互矛盾的结果。然而，家庭空气污染(HAP)是COPD的主要危险因素，在以前的分析中大多没有考虑到，也从未客观测量过。我们的目的是比较低资源高地和低地之间COPD的患病率及其危险因素，特别关注客观测量的HAP。我们在吉尔吉斯斯坦农村的高地(海拔约2050米)和低地(海拔约750米)进行了一项基于人群的观察性研究。我们在随机选择的家庭中进行了肺量测定，测量了空气动力学直径为2.5微米的室内颗粒物(PM2.5)，并对其他COPD危险因素进行了问卷调查。采用描述性统计和多变量logistic回归进行分析。我们包括392名参与者:199名高地人和193名低地人。COPD在高地居民中更为普遍(36.7%对10.4%;术中,0.001)。他们的平均PM2.5暴露量也更高(290.0µg·m−3 vs 72.0µg·m−3; p<0.001). In addition to high PM2.5 exposure (OR 3.174, 95% CI 1.061–9.493), the altitude setting (OR 3.406, 95% CI 1.483–7.825), pack-years of smoking (OR 1.037, 95% CI 1.005–1.070) and age (OR 1.058, 95% CI 1.037–1.079) also contributed to a higher COPD prevalence among highlanders.COPD prevalence and HAP were highest in the highlands, and were independently associated. Preventive interventions seem warranted in these low-resource, highland settings. With this study being one of the first spirometry-based prevalence studies in Central Asia, generalisability needs to be assessed.High indoor PM2.5 levels could explain elevated COPD prevalence in rural, high-altitude settings: prevention is key! http://ow.ly/hvC930mFEKJ ER -