Ty-Jour T1 - 肺动脉高压病病病病病病病病病病病毒学：艺术状态和研究视角JF - 欧洲呼吸期刊Jo - Eur Respir J Do - 10.1183 / 13993003.01887-2018 VL - 53 IS - 1 SP - 1801887 Au - Humbert，MarcAu - Guignabert，Christophe Au - Bonnet，SébastienAU - Dorfmüller，彼得奥利尔 - Klinger，James R. Au - Nicolls，Mark R. Au - Olschewski，Andrea J. Au - Purlamsetti，Soni S. Au - Schermuly，Ralpht T.Au - Stenmark，Kurt R. Au - Rabinovitch，Marlene Y1 - 2019/01/01 UR - //www.qdcxjkg.com/content/53/1/1801887.abstract n2 - 临床和翻译研究发挥了重要的role in advancing our understanding of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms of PH with severe vascular remodelling (e.g. chronic thromboembolic PH and pulmonary veno-occlusive disease). However, PH remains an incurable condition with a high mortality rate, underscoring the need for a better transfer of novel scientific knowledge into healthcare interventions. Herein, we review recent findings in pathology (with the questioning of the strict morphological categorisation of various forms of PH into pre- or post-capillary involvement of pulmonary vessels) and cellular mechanisms contributing to the onset and progression of pulmonary vascular remodelling associated with various forms of PH. We also discuss ways to improve management and to support and optimise drug development in this research field.State of the art and research perspectives in the cellular and molecular basis and pathology of pulmonary vascular remodelling associated with various forms of pulmonary hypertension http://ow.ly/cjwp30mgzmH ER -