RT期刊文章SR电子T1 COPD生物标志物s and phenotypes: opportunities for better outcomes with precision imaging JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1801570 DO 10.1183/13993003.01570-2018 VO 52 IS 5 A1 Washko, George R. A1 Parraga, Grace YR 2018 UL //www.qdcxjkg.com/content/52/5/1801570.abstract AB A number of chronic diseases have benefited from both imaging and personalised medicine, but unfortunately, for patients with chronic obstructive pulmonary disease (COPD), there has been little clinical uptake or recognition of the key advances in thoracic imaging that might help detect disease early, or, perhaps more importantly, might help develop and phenotype patients for novel or personalised therapies that may halt disease progression. We outline our vision for how computed tomography and magnetic resonance imaging may be used to better inform COPD patient care, and, perhaps more importantly, how these may be used to help develop new therapies directed at early disease. We think that imaging and precision medicine should be considered and used together as “precision imaging” at specific stages of COPD when the major pathologies may be more responsive to therapy. While “precision medicine” is the tailoring of medical treatment to individual patients, we define “precision imaging” as the tailoring of specific therapies and interventions to individual patients with a detailed quantitative understanding of their specific imaging phenotypes and measurements. Finally, we stress the importance of “seeing” the pathology, because without this understanding, you can neither treat nor cure patients with COPD.COPD imaging has not improved outcomes in patients with advanced lung disease. For patients to benefit, imaging phenotypes must be developed that reflect early, reversible disease or be used in a more pragmatic fashion to improve clinical outcomes. http://ow.ly/i19g30m7f2I