TY - Jour T1 - 孕妇血压和高血压障碍在怀孕期间和儿童呼吸疾病：GONAGEST R SCHIES JF - 欧洲呼吸杂志Jo - EUR RESPIR J DO - 10.118378-2018 VL - 52是 - 5 SP - 1800378 AU -Wilmink, Freke A. AU - den Dekker, Herman T. AU - de Jongste, Johan C. AU - Reiss, Irwin K.M. AU - Jaddoe, Vincent W.V. AU - Steegers, Eric A. AU - Duijts, Liesbeth Y1 - 2018/11/01 UR - //www.qdcxjkg.com/content/52/5/1800378.abstract N2 - Pre-eclampsia is associated with an increased risk of bronchopulmonary dysplasia, wheezing and asthma in later childhood. Currently, there are no studies available investigating maternal blood pressure measurements during multiple time-points in pregnancy and respiratory outcome measures in the child.We examined the associations of maternal blood pressure and hypertensive disorders with the risk of lower lung function, wheezing and asthma in children aged 10 years. This study among 4894 children was embedded in a population-based prospective cohort study. We used multivariate analyses, taking lifestyle and socioeconomic factors into account.We observed consistent associations per 5 mmHg higher maternal blood pressure in early pregnancy with a lower forced expiratory volume in 1 s/forced vital capacity ratio (z-score −0.03 (95% CI −0.05– −0.01)) and per 5 mmHg higher blood pressure in late pregnancy with a higher risk for current wheezing and current asthma (OR 1.07 (95% CI 1.02–1.12) and 1.06 (95% CI 1.00–1.11), respectively). We found no associations of maternal hypertensive disorders during pregnancy with child lung function, current wheezing or current asthma.Our results suggest that higher blood pressure in pregnant women is associated with lower lung function and increased risks of current wheezing and current asthma in children. The associations may be trimester specific.Higher blood pressure in pregnant women is associated with lower lung function, wheezing and asthma in children http://ow.ly/R9MI30m92GM ER -