JF -欧洲呼吸杂志JO - Eur Respir J DO - 10.1183/1399300 .国会-2018。PA1328六世- 52 - 5 62 SP - PA1328 AU -恩格尔,托拜厄斯盟——一致,艾伦盟——Vanden Driessche柯恩盟——Reijers Monique AU -梅尔彻,威廉盟——Merkus彼得盟——Verweij保罗Y1 - 2018/09/15 UR - //www.qdcxjkg.com/content/52/suppl_62/PA1328.abstract N2 -背景:到目前为止没有研究调查已经完成了真菌的分泌囊性纤维化(CF)的病人。然而，殖民地性纤维化患者的高真菌负荷可能提示真菌通过咳嗽分泌物传播。目的和目的:我们调查了烟曲霉在慢性定植性纤维化患者咳嗽时的微生物传播情况，相对于典型的细菌性纤维化病原体。方法:以烟曲霉为菌落的成年CF患者在2个不同的“咳嗽板”上分别咳嗽2次，一个含真菌培养基，一个含细菌培养基。同时收集痰标本。如果在咳嗽板和痰标本上同时分离熏蒸菌，进行短串联重复(STR)基因分型。相同的STR基因型被认为是分泌的证据。结果:15例患者进行了20例咳嗽板检查。在11份痰标本(9例)中培养熏蒸菌。11个痰培养阳性的评估中有2个(18%)在咳嗽板上也显示烟熏菌的生长。 In one patient secretion was demonstrated with an identical STR genotype of the secreted fungus and all A. fumigatus cultured in the current and previous sputum samples. The other patient showed four unique A. fumigatus in the sputum culture of which none was identical to the fungus cultured on the cough plate. All CBA cough plates showed bacterial growth. The transmission frequencies of bacterial pathogens was: Pseudomonas aeruginosa, 60%; Staphylococcus aureus, 8.3%.Conclusion: This is the first study that shows secretion of A. fumigatus in a CF patient during coughing.FootnotesCite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA1328.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -