@Article {Hallstrand1801033，作者= {Hallstrand，Teal S.和Leuppi，Joerg D.和Joos D.和Joos，Guy and Hall，Graham L.和Carlsen，Kai-H {\ r A} Kon and Koninsky，Kon and Kaminsky，David A.和Coates，Allan，AllanL.和Cockcroft，Donald〜W。以及Culver，Bruce H.和Diamant，Zuzana和Gauvreau，Gail〜m。和Horvath，Ildiko和De Jongh，Frans H.C.和Laube，Beth L.和Sterk，Peter J.和Wanger，Jack}，Editor = {，}，Title = {ERS支气管挑战测试的技术标准：间接气道挑战的病理生理学和方法论}，音量= {52}，number = {5}，Elocation-id = {1801033}，年= {2018}，doi = {10.1183/13993003.01033-2018}，Publisher = {欧洲呼吸社会}188bet官网地址支气管挑战测试的一般考虑和甲基酚挑战测试的性能，{\ textquotedblleft}直接{\ textquotedblright}气道挑战测试。在这里，工作队提供了有关病理生理学和进行间接挑战测试的方法的更新描述。由于间接挑战测试通过激活与哮喘有关的内源性途径的激活触发气道狭窄，因此间接挑战测试往往是针对哮喘的特定的，并且揭示了有关哮喘生物学的广泛性，但对于检测气道检测的直接测试可能不太敏感反应性过高。我们为高点挑战测试的行为和解释提供了建议，例如干空气运动挑战和Eucapnic自愿性高点，为气道变窄提供了一种强烈的刺激。 This technical standard expands the recommendations to additional indirect tests such as hypertonic saline, mannitol and adenosine challenge that are incremental tests, but still retain characteristics of other indirect challenges. Assessment of airway hyperresponsiveness, with direct and indirect tests, are valuable tools to understand and to monitor airway function and to characterise the underlying asthma phenotype to guide therapy. The tests should be interpreted within the context of the clinical features of asthma.This international task force recently reported the general considerations for {\textquotedblleft}direct{\textquotedblright} bronchoprovocation testing. In the present document, the task force provides updated recommendations on the pathophysiology and conduct of {\textquotedblleft}indirect{\textquotedblright} challenge tests. http://ow.ly/FR1K30m99Ef}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/52/5/1801033}, eprint = {//www.qdcxjkg.com/content/52/5/1801033.full.pdf}, journal = {European Respiratory Journal} }