使用通风磁共振成像和多呼吸冲洗JF欧洲呼吸杂志JO欧洲呼吸ĴFD欧洲呼吸协会SP 1800821 DO 10.1183 / 13993003.00821-2018 VO 52 5 A1史密斯在囊性纤维化肺区域生理学RT期刊论文SR电子T1模式188bet官网地址, Laurie J. A1 Collier, Guilhem J. A1 Marshall, Helen A1 Hughes, Paul J.C. A1 Biancardi, Alberto M. A1 Wildman, Martin A1 Aldag, Ina A1 West, Noreen A1 Horsley, Alex A1 Wild, Jim M. YR 2018 UL //www.qdcxjkg.com/content/52/5/1800821.abstract AB Hyperpolarised helium-3 (3He) ventilation magnetic resonance imaging (MRI) and multiple-breath washout (MBW) are sensitive methods for detecting lung disease in cystic fibrosis (CF). We aimed to explore their relationship across a broad range of CF disease severity and patient age, as well as assess the effect of inhaled lung volume on ventilation distribution.32 children and adults with CF underwent MBW and 3He-MRI at a lung volume of end-inspiratory tidal volume (EIVT). In addition, 28 patients performed 3He-MRI at total lung capacity. 3He-MRI scans were quantitatively analysed for ventilation defect percentage (VDP), ventilation heterogeneity index (VHI) and the number and size of individual contiguous ventilation defects. From MBW, the lung clearance index, convection-dependent ventilation heterogeneity (Scond) and convection–diffusion-dependent ventilation heterogeneity (Sacin) were calculated.VDP and VHI at EIVT strongly correlated with lung clearance index (r=0.89 and r=0.88, respectively), Sacin (r=0.84 and r=0.82, respectively) and forced expiratory volume in 1 s (FEV1) (r=−0.79 and r=−0.78, respectively). Two distinct 3He-MRI patterns were highlighted: patients with abnormal FEV1 had significantly (p<0.001) larger, but fewer, contiguous defects than those with normal FEV1, who tended to have numerous small volume defects. These two MRI patterns were delineated by a VDP of ∼10%. At total lung capacity, when compared to EIVT, VDP and VHI reduced in all subjects (p<0.001), demonstrating improved ventilation distribution and regions of volume-reversible and nonreversible ventilation abnormalities.Ventilation distribution on MRI improves at TLC and two distinct patterns of regional lung disease in CF are highlighted, where abnormal FEV1 is associated with VDP >10%. Ventilation MRI and MBW are highly correlated. http://ow.ly/NvyS30lOP4O