TY -的T1 -结构分析表明heterogeneous [¹⁸F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01138-2018 VL - 52 IS - 5 SP - 1801138 AU - Aliyu, Shamsuddeen A. AU - Avery, Ged AU - Cawthorne, Christopher AU - Archibald, Stephen J. AU - Kadir, Timor AU - Willaime, Julien M.Y. AU - Morice, Alyn H. AU - Hart, Simon P. AU - Crooks, Michael G. Y1 - 2018/11/01 UR - //www.qdcxjkg.com/content/52/5/1801138.abstract N2 - Recently, positron emission tomography (PET)–computed tomography (CT) imaging in idiopathic pulmonary fibrosis (IPF) has revealed increased [18F]-fluorodeoxyglucose ([18F]-FDG) uptake both in fibrotic lung and areas of lung with a normal radiological appearance on high-resolution computed tomography (HRCT) [1, 2]. IPF is characterised by heterogeneous fibrosis at the tissue level, so to gain insight into the early “microscopic” disease process we used established textural features [3, 4] to evaluate heterogeneity of [18F]-FDG uptake in radiologically normal lung in patients with IPF.Textural analysis demonstrates increased heterogeneity of [18F]-FDG uptake in normal lung (on CT) in patients with IPF. Molecular imaging of the lungs using PET can be used to study early disease in IPF before CT abnormalities are apparent. http://ow.ly/T82W30lGU0X ER -