TY - T1的早发性哮喘增加childhood obesity risk? A pooled analysis of 16 European cohorts JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00504-2018 VL - 52 IS - 3 SP - 1800504 AU - Contreras, Zuelma A. AU - Chen, Zhanghua AU - Roumeliotaki, Theano AU - Annesi-Maesano, Isabella AU - Baïz, Nour AU - von Berg, Andrea AU - Bergström, Anna AU - Crozier, Sarah AU - Duijts, Liesbeth AU - Ekström, Sandra AU - Eller, Esben AU - Fantini, Maria P. AU - Kjaer, Henrik Fomsgaard AU - Forastiere, Francesco AU - Gerhard, Beatrix AU - Gori, Davide AU - Harskamp-van Ginkel, Margreet W. AU - Heinrich, Joachim AU - Iñiguez, Carmen AU - Inskip, Hazel AU - Keil, Thomas AU - Kogevinas, Manolis AU - Lau, Susanne AU - Lehmann, Irina AU - Maier, Dieter AU - van Meel, Evelien R. AU - Mommers, Monique AU - Murcia, Mario AU - Porta, Daniela AU - Smit, Henriëtte A. AU - Standl, Marie AU - Stratakis, Nikos AU - Sunyer, Jordi AU - Thijs, Carel AU - Torrent, Maties AU - Vrijkotte, Tanja G.M. AU - Wijga, Alet H. AU - Berhane, Kiros AU - Gilliland, Frank AU - Chatzi, Leda Y1 - 2018/09/01 UR - //www.qdcxjkg.com/content/52/3/1800504.abstract N2 - The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3–4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3–4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18–2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31–3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08–2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.Children who have asthma or wheezing in early childhood may be at a higher risk of developing obesity http://ow.ly/HfKw30lhF3X ER -