TY - T1的呼吸器的神经控制y sensations is associated with increased dyspnoea perception JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00559-2018 VL - 52 IS - 1 SP - 1800559 AU - Herzog, Michaela AU - Sucec, Josef AU - Van Diest, Ilse AU - Van den Bergh, Omer AU - Chan, Pei-Ying Sarah AU - Davenport, Paul AU - von Leupoldt, Andreas Y1 - 2018/07/01 UR - //www.qdcxjkg.com/content/52/1/1800559.abstract N2 - According to the neural gating model of respiratory sensations, breathing occurs under normal conditions automatically without reaching consciousness (gating-out). This neural filter mechanism prevents the brain from being flooded with irrelevant respiratory sensations leaving sufficient neural processing capacities for everyday activities [1, 2]. However, in some circumstances, breathing can become conscious either voluntarily (e.g. attention, meditation) or due to increased respiratory demand (e.g. exacerbations, respiratory disease). In such cases, respiratory information is no longer filtered out but transmitted to higher brain centres which leads to the allocation of attentional resources towards the breathing sensation and brings it to conscious awareness (gating-in) [1, 2]. Similar to the neural gating in other modalities, such as auditory/visual/somatosensory gating [3, 4], this respiratory gating mechanism is, therefore, the neural basis for monitoring respiratory functioning and a pre-requisite for subsequent adaptive behaviour, such as medication intake or physician visits. Anxiety, which is prevalent in patients with dyspnoea [1, 5], has been shown to be associated with reduced neural gating of respiratory sensations, suggesting gating deficits to be a potential mechanism for the documented over-perception of dyspnoea in anxious individuals [6, 7]. The neural gating model of respiratory sensations implies that decreased neural gating of respiratory sensations is associated with increasing dyspnoea [4]. However, this implication has never been tested and was investigated in the present study by using respiratory-related evoked potentials (RREP) in the electroencephalogram (EEG) while additionally exploring potential effects of anxiety.Reduced respiratory neural gating is associated with increased dyspnoea, particularly in high anxious individuals http://ow.ly/xW4B30k34KRWe thank Thierry Troosters for his valuable and critical evaluation of the present findings and previous versions of this manuscript. ER -