TY - T1的不良呼吸的影响开始钟声ids for chronic breathlessness: to what extent can we learn lessons from chronic pain? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00882-2018 VL - 52 IS - 1 SP - 1800882 AU - Verberkt, Cornelia A. AU - van den Beuken-van Everdingen, Marieke H.J. AU - Schols, Jos M.G.A. AU - Datla, Sushma AU - Dirksen, Carmen D. AU - Johnson, Miriam J. AU - van Kuijk, Sander M.J. AU - Wouters, Emiel F.M. AU - Janssen, Daisy J.A. Y1 - 2018/07/01 UR - //www.qdcxjkg.com/content/52/1/1800882.abstract N2 - We would like to thank K.T.S. Pattinson and colleagues for their interest in our review and their comprehensive comments [1]. We agree that the quality of the included studies was low, and the studies were small and not designed to examine the safety of opioids, as stated in our discussion [2]. Indeed, respiratory depression was not included as an outcome in over half of the studies. Of note, in the 25 studies that did include the outcome, only 11 stated a definition. Therefore, we recommended in our review to include “a common respiratory outcome set in all trials of opioids for breathlessness, so that a more robust synthesis could be conducted”. Although chemoreflex response is useful in laboratory research, measurement of blood gases remains the basis for evaluation in clinical practice, with the assessment of arterial blood gases being more reliable than the assessment of capillary blood gases [3] or transcutaneous measurement [4].Chronic breathlessness: care must be taken not to generalise evidence on adverse effects of opioids from chronic pain inappropriately http://ow.ly/D7sR30kfskS ER -