TY -的T1 -鼻咽吸入pa的价值ediatric chronic lower respiratory tract illness JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01783-2017 VL - 51 IS - 6 SP - 1701783 AU - Lunardi, Francesca AU - Vuljan, Stefania Edith AU - Perissinotto, Egle AU - Pezzuto, Federica AU - Malacrida, Sandro AU - Bugin, Samuela AU - Bertozzi, Ilaria AU - Snijders, Deborah AU - Rizzo, Stefania AU - Barbato, Angelo AU - Calabrese, Fiorella Y1 - 2018/06/01 UR - //www.qdcxjkg.com/content/51/6/1701783.abstract N2 - Respiratory viruses are a common cause of illness in children and are responsible for high morbidity and hospitalisation [1]. The role of infectious agents in chronic/recurrent lower respiratory tract illness (LRTI) is not clearly defined, whereas it is well known in acute forms and in exacerbation of respiratory diseases [2–4]. We have previously demonstrated a high frequency of viruses, particularly human rhinovirus (HRV), in children affected by chronic/recurrent LRTI whose bronchoalveolar lavage (BAL) showed changes in cellularity and inflammatory cytokines [5]. BAL is the gold standard for sensitive detection of infective agents of the lower respiratory tract, even if invasive. Nasopharyngeal aspirate (NPA), nasopharyngeal swab and nasal wash have been investigated to find an easier and more reliable technique for viral diagnosis but never in children affected by different forms of chronic/recurrent LRTI [6–8]. Our study aimed to investigate the presence of viral genomes testing the value of NPA in comparison with BAL in a large paediatric population affected by different forms of chronic/recurrent LRTI.Nasopharyngeal aspirate as a sensitive and specific surrogate tool for the detection of respiratory viruses in different forms of chronic/recurrent lower respiratory tract illness http://ow.ly/cd8S30jcwyu ER -