作者@article {Sun1800329 ={太阳,Yi-Qian和Brumpton, Ben M. and Bonilla, Carolina and Lewis, Sarah J. and Burgess, Stephen and Skorpen, Frank and Chen, Yue and Nilsen, Tom I.L. and Romundstad, P{\r a}l Richard and Mai, Xiao-Mei}, title = {Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study}, volume = {51}, number = {6}, elocation-id = {1800329}, year = {2018}, doi = {10.1183/13993003.00329-2018}, publisher = {European Respiratory Society}, abstract = {We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D (25(OH)D) levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomisation analysis using a prospective cohort study in Norway, including 54 580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on the vitamin D-increasing alleles rs2282679, rs12785878 and rs10741657. Hazard ratios with 95\% confidence intervals for incidence of lung cancer and histologic types were estimated in relation to the allele score. The inverse-variance weighted method using summarised data of individual single nucleotide polymorphisms was applied to calculate the Mendelian randomisation estimates.The allele score accounted for 3.4\% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR 0.99 (95\% CI 0.93{\textendash}1.06) per allele score. A 25 nmol{\textperiodcentered}L-1 increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (Mendelian randomisation estimate HR 0.96, 95\% CI 0.54{\textendash}1.69) or any histologic type.Mendelian randomisation analysis did not suggest a causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study.Mendelian randomisation study did not suggest causal association between serum 25-hydroxyvitamin D and lung cancer risk http://ow.ly/UOJ630jGVh1}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/51/6/1800329}, eprint = {//www.qdcxjkg.com/content/51/6/1800329.full.pdf}, journal = {European Respiratory Journal} }