@文章{Thacher1702111,作者= {Thacher, Jesse D. and Schultz, Erica S. and Hallberg, Jenny and Hellberg, Ulrika and Kull, Inger and Thunqvist, Per and Pershagen, G{\"o}ran and Gustafsson, Per m . and Mel{\'e}n, Erik and Bergstr{\"o}m, Anna},标题={早期生活和青春期烟草烟雾暴露与肺功能的关系},volume = {51}, number ={6},位置-id = {1702111}, year = {2018}, doi ={10.1181 /13993003.02111-2017},出版商={欧洲呼吸学会},188bet官网地址母亲在怀孕期间吸烟与年幼儿童的肺功能受损有关,但对青少年吸烟的长期影响和影响知之甚少。我们调查了母亲在怀孕期间吸烟、二手烟暴露和青少年吸烟对16岁时肺功能的影响。BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology)出生队列通过重复的问卷调查收集了参与者接触烟草烟雾的信息,并测量了16岁时唾液中可代宁的浓度。参与者在16岁时进行了肺活量测量和脉冲振荡测量(IOS) (n=2295)。孕妇在怀孕期间暴露于吸烟环境与1秒用力呼气量(FEV1)/用力肺活量(FVC)比值降低相关(95% CI -2.0至-0.2 %)。在怀孕期间接触母亲吸烟的参与者中,IOS在5{\textendash}20 Hz (R5{\textendash}20)时表现出更大的阻力。吸烟的青少年在R5{textendash}20中FEV1/FVC比值降低至-0.9 % (95% CI为-1.8至-0.1 %),抵抗力增加至6.5 Pa{\textperiodcentered}L{\textendash}1{\textperiodcentered}s (95% CI为0.7至12.2 Pa{\textperiodcentered}L{\textendash}1{\textperiodcentered}s)。使用>=12 ng (\textperiodcentered) mL-1作为青少年吸烟的临界值,可替宁浓度与FEV1/FVC比值具有可比性的相关性。怀孕期间母亲吸烟与FEV1/FVC比值降低和气道阻力增加有关。此外,青少年吸烟似乎与FEV1/FVC比值降低和外周气道阻力增加有关。Maternal smoking in utero and teenage smoking are associated with indices of airway obstruction at age 16 years http://ow.ly/NwF030jFS2W}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/51/6/1702111}, eprint = {//www.qdcxjkg.com/content/51/6/1702111.full.pdf}, journal = {European Respiratory Journal} }