% 0期刊文章%基督教Gerges %一个马里奥Gerges %皮埃尔Fesler %安娜玛丽亚Pistritto %尼古拉斯·P·Konowitz %一个大卫·s·斯里马杰Johannes Jakowitsch % %艾琳·m·朗% T深入血液动力学的表型出现由于左肺动脉高血压心脏病的2018% % D J R 10.1183/13993003.00067 -2018%欧洲呼吸杂志% P 1800067 % V 51% N 5% X肺动脉高压(PH)的最常见原因是心脏病(方面)。当前分类系统的定义PH-LHD正在审查中。因此我们深入进行潜在入侵血液动力学的表现型来评估网站PH-LHD增加肺血管阻力(PVR)的子集。根据肺动脉闭塞波形产生有效的毛细管压力的估计,我们分区PVR在较大的动脉(Rup,上游阻力)和小动脉以及静脉组件(Rds,下游阻力)。在Rup小血管疾病的情况下,减少和增加Rds。吸入一氧化氮(NO)测试是用来评估急性vasoreactivity。右心室后负荷(PVR),肺动脉合规、有效动脉倒电容)明显高于在合并后和pre-capillary PH值(Cpc-PH, n = 35)比孤立post-capillary PH值(Ipc-PH, n = 20)。右心室后负荷减少吸入期间没有Cpc-PH和特发性肺动脉高血压(n = 31),但在Ipc-PH保持不变。Rup是类似于Cpc-PH(66.8±10.8%)和特发性肺动脉高血压(65.0±12.2%;p = 0.530)显示小血管疾病,但明显高于Ipc-PH (96.5±4.5%; p<0.001) suggesting upstream transmission of elevated left atrial pressure.Right ventricular afterload is driven by elevated left atrial pressure in Ipc-PH and is further increased by elevated small vessel resistance in Cpc-PH. Cpc-PH is responsive to inhaled NO. Our data support current definitions of PH-LHD subsets.Combined post- and pre-capillary PH is characterised by pre-capillary pulmonary vascular disease and a positive response to inhaled NO http://ow.ly/G2nF30iYTeJ %U //www.qdcxjkg.com/content/erj/51/5/1800067.full.pdf