TY -的T1 - DNA甲基化在气道年代模块mooth muscle are associated with asthma severity JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01068-2017 VL - 51 IS - 4 SP - 1701068 AU - Perry, Mark M. AU - Lavender, Paul AU - Kuo, Chih-hsi Scott AU - Galea, Francesca AU - Michaeloudes, Charalambos AU - Flanagan, James M. AU - Fan Chung, Kian AU - Adcock, Ian M. Y1 - 2018/04/01 UR - //www.qdcxjkg.com/content/51/4/1701068.abstract N2 - Asthma is a chronic airway inflammatory disorder characterised by airway hyperresponsiveness, inflammation and remodelling, including airway smooth muscle cell (ASMC) hyperplasia and subepithelial airway fibrosis [1, 2]. ASMCs from severe asthmatics are hyperproliferative, release more pro-inflammatory cytokines and are corticosteroid-insensitive compared with those from healthy individuals and non-severe asthma patients [3, 4]. Genetic and epigenetic processes such as miRNA expression and DNA methylation have been implicated in asthma pathogenesis [5]. Indeed, DNA methylation is altered in asthmatic blood cells [5] and may be a biomarker of atopy [6].Abnormal DNA methylation patterns distinguish airway smooth muscle cell function in asthma and asthma severity http://ow.ly/cTrK30iCwVK ER -