PT - JOURNAL ARTICLE AU - Çolak, Yunus AU - Afzal, Shoaib AU - Nordestgaard, Børge G. AU - Vestbo, Jørgen AU - Lange, Peter TI -根据正常而非固定比率的下限限制气流的中青年成人发病率高，生存率差:基于人群的前瞻性队列研究AID - 10.1183/13993003.02681-2017 DP - 2018年3月01日TA -欧洲呼吸杂志PG - 1702681 VI - 51 IP - 3 4099 - //www.qdcxjkg.com/content/51/3/1702681.short 4100 - //www.qdcxjkg.com/content/51/3/1702681.full SO - Eur Respir J2018年3月01日;51 AB -使用固定比率定义气流限制(AFL)的假定后果是老年人的过度诊断和年轻人的诊断不足。然而，有潜在诊断不足的AFL的年轻个体的预后描述很少。我们假设年轻时AFL的潜在诊断不足与预后不良有关。我们将哥本哈根普通人群研究中年龄在20-100岁的95 288名参与者分为以下组:无AFL, 1秒用力呼气量(FEV1)/用力肺活量(FVC)≥0.70且≥正常下限(LLN) (n=78 779,83%);FEV1/FVC≥0.70和<LLN (n= 1056,1%)的潜在未确诊AFL患者;FEV1/FVC <0.70且LLN≥(n= 3088,3%)的潜在过度诊断AFL患者;FEV1/FVC <0.70和<LLN的AFL患者(n=12 365, 13%)。我们评估了急性加重、肺炎、缺血性心脏病、心力衰竭和全因死亡率的风险。 Median follow-up was 6.0 years (range: 2 days–11 years).Compared to individuals without AFL, individuals with potentially underdiagnosed AFL had an increased risk of morbidity and mortality with age- and sex-adjusted hazard ratios (HR) of 2.7 (95% CI: 1.7–4.5) for pneumonias, 2.3 (95% CI: 1.2–4.5) for heart failure, and 3.1 (95% CI: 2.1–4.6) for all-cause mortality.Young and middle-aged adults with AFL according to LLN but not fixed ratio experience increased respiratory and cardiovascular morbidity and early death.Young and middle-aged adults with airflow limitation according to LLN but not fixed ratio have poor prognosis http://ow.ly/QwOP30iiU11