TY - T1的致癌作用的生物标志物和你mour growth in patients with cutaneous melanoma and obstructive sleep apnoea JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01885-2017 VL - 51 IS - 3 SP - 1701885 AU - Santamaria-Martos, Fernando AU - Benítez, Ivan AU - Girón, Cristina AU - Barbé, Ferran AU - Martínez-García, Miguel-Angel AU - Hernández, Luis AU - Montserrat, Josep M. AU - Nagore, Eduardo AU - Martorell, Antonio AU - Campos-Rodriguez, Francisco AU - Corral, Jaime AU - Cabriada, Valentin AU - Abad, Jorge AU - Mediano, Olga AU - Troncoso, Maria F. AU - Cano-Pumarega, Irene AU - Fortuna Gutierrez, Ana Maria AU - Diaz-Cambriles, Trinidad AU - Somoza-Gonzalez, Maria AU - Almendros, Isaac AU - Farre, Ramon AU - Gozal, David AU - Sánchez-de-la-Torre, Manuel A2 - , Y1 - 2018/03/01 UR - //www.qdcxjkg.com/content/51/3/1701885.abstract N2 - The goal of this study was to assess the relationship between the severity of obstructive sleep apnoea (OSA) and the levels of carcinogenesis- and tumour growth-related biomarkers in patients with cutaneous melanoma.This multicentre observational study included patients who were newly diagnosed with melanoma. The patients were classified as non-OSA (apnoea–hypopnoea index (AHI) 0–5 events·h−1), mild OSA (AHI 5–15 events·h−1) and moderate–severe OSA (AHI >15 events·h−1). ELISAs were performed to analyse the serum levels of hypoxia- and tumour adhesion-related biomarkers (vascular endothelial growth factor (VEGF), interleukin (IL)-8, intracellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM)-1) and markers of tumour aggressiveness (S100 calcium-binding protein B (S100B) and melanoma inhibitory activity (MIA)). A logistic model adjusted for age, sex and body mass index was fitted to each biomarker, and the AHI served as the dependent variable.360 patients were included (52.2% male, median (interquartile range) age 55.5 (43.8–68.0) years and AHI 8.55 (2.8–19.5) events·h−1). The levels of VEGF, IL-8, ICAM-1, S100B and MIA were not related to the severity of OSA. The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: odds ratio (OR) 2.07, p=0.021; moderate–severe OSA: OR 2.35, p=0.013).In patients with cutaneous melanoma, OSA was associated with elevated circulating levels of VCAM-1 that could indicate the contribution of OSA in tumorigenesis via integrin-based adhesion.In patients with cutaneous melanoma, OSA is associated with increased expression of a biomarker of tumorigenesis http://ow.ly/mLo430i9Z8j ER -