作者@article {Dijk1701377 = {F。妮可·狄克和徐美特斯邦威和埃里克·梅尔{}\ ' e n Anne-Elie Carsin Asish Kumar和伊利亚·m·诺尔特和名Gruzieva和戈兰Pershagen Neomi ~。Grotenboer E.M. Savenije奥尔加和约瑟玛丽亚Ant {\ ' o}和虹膜Lavi Carlota Doba {\ ~ n} o和琼Bousquet Pieter van der沼泽和拉尔夫·摩根大通(J.P. van der Valk和约翰·c . de Jongste卡坦c . Nawijn先生和斯特凡诺Guerra Dirkje Postma和杰拉德·h·Koppelman}, title = {IL1RL1甲基化和IL1RL1-a蛋白质水平的基因调控在哮喘},体积= {51}= {3},elocation-id = {1701377} = {2018}, doi ={10.1183/13993003.01377 -2017},出版商={欧洲呼吸学会},文摘= {\ textendash}和{Interleukin-1受体1 (IL1RL1)是一个重要的哮喘基因。188bet官网地址(Epi)遗传调节IL1RL1蛋白表达尚未建立。我们评估之间的联系IL1RL1单核苷酸多态性(snp), IL1RL1甲基化和血清IL1RL1-a蛋白质水平,旨在识别因果通路在哮喘。协会IL1RL1 snp在荷兰哮喘哮喘测定全基因组关联研究队列和三个欧洲同期出生的,BAMSE(儿童/谷仓,过敏,环境,斯德哥尔摩,流行病学调查),INMA (Infancia y五分镍币环境)和PIAMA(预防和哮喘的发病率和螨虫过敏),参与机制过敏研究的发展。我们执行血IL1RL1 DNA甲基化数量性状位点(QTL)定位分析(n = 496)和(epi)全基因组蛋白质QTL分析血清IL1RL1-a水平(n = 1462)。我们调查了协会IL1RL1 CpG甲基化与哮喘(n = 632)和IL1RL1-a水平(n = 548),与随后的因果推理测试。最后,我们决定协会IL1RL1-a水平与哮喘及其临床特征(n = 1101)。IL1RL1患哮喘的危险snp与IL1RL1甲基化(rs1420101;p = 3.7 {\ texttimes} 10到16)和血清IL1RL1-a水平(p = 2.8 {\ texttimes} 10-56)。 IL1RL1 methylation was not associated with asthma or IL1RL1-a levels. IL1RL1-a levels negatively correlated with blood eosinophil counts, whereas there was no association between IL1RL1-a levels and asthma.In conclusion, asthma-associated IL1RL1 SNPs strongly regulate IL1RL1 methylation and serum IL1RL1-a levels, yet neither these IL1RL1-methylation CpG sites nor IL1RL1-a levels are associated with asthma.Interleukin-1 receptor-like 1 (IL1RL1) SNPs regulate IL1RL1-methylation and serum IL1RL1-a levels, yet these effects are not related to asthma http://ow.ly/AStC30hSvGy}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/51/3/1701377}, eprint = {//www.qdcxjkg.com/content/51/3/1701377.full.pdf}, journal = {European Respiratory Journal} }