TY - T1的呼吸道感染、系统性inflammation and lung clearance index in children and adults with cystic fibrosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01704-2017 VL - 51 IS - 2 SP - 1701704 AU - O'Neill, Katherine AU - Bradley, Judy M. AU - Reid, Alastair AU - Downey, Damian G. AU - Rendall, Jacqueline AU - McCaughan, John AU - Moore, John E. AU - Tunney, Michael M. AU - Elborn, J. Stuart Y1 - 2018/02/01 UR - //www.qdcxjkg.com/content/51/2/1701704.abstract N2 - The lung clearance index (LCI) is a measure of ventilation distribution derived from multiple breath washout (MBW). It is a promising measure for monitoring early lung disease in cystic fibrosis (CF) [1–4] and is increasingly being used as a surrogate efficacy endpoint in CF clinical trials [5, 6]. LCI is reliable and more sensitive than forced expiratory volume in 1 s (FEV1) in detecting lung disease in infants, children and adults with CF [7–9], tracks early disease progression and symptoms [3], and predicts the onset of pulmonary exacerbations [10]. LCI has been shown to be elevated in infants and younger children with respiratory infection and correlates with airway inflammation, measured using a range of biomarkers in bronchoalveolar lavage [11–13]. However, there are few data on how LCI relates to markers of infection and inflammation in children >6 years and adults.LCI is a sensitive marker of infection and inflammation in clinically stable children and adults with cystic fibrosis http://ow.ly/vumZ30hzHL0 ER -