TY -的T1 -呼出nitri持续升高c oxide fraction is associated with increased risk of exacerbation in COPD JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01457-2017 VL - 51 IS - 1 SP - 1701457 AU - Alcázar-Navarrete, Bernardino AU - Ruiz Rodríguez, Oliverio AU - Conde Baena, Pablo AU - Romero Palacios, Pedro José AU - Agusti, Alvar Y1 - 2018/01/01 UR - //www.qdcxjkg.com/content/51/1/1701457.abstract N2 - Preventing the occurrence of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is a major therapeutic goal. We hypothesise that persistently increased levels of exhaled nitric oxide (FeNO) during follow-up can identify a group of COPD patients at higher risk of AECOPD.To test this hypothesis, we measured FeNO levels (HypAir FeNO®, Medisoft; Sorinnes, Belgium) prospectively in 226 clinically stable COPD outpatients at recruitment and during follow-up (at 6 and 12 months). Patients were stratified according to the number of visits with FeNO ≥20 ppb.FeNO was <20 ppb in all three visits in 44.2% of patients, 29.6% in visit 1 and 26.1% in visit 2 or 3. These three groups suffered progressively higher AECOPD rates during follow-up (0.67, 0.91 and 1.42, respectively, p<0.001). After adjusting for potential confounding variables (log-rank test), the hazard ratio for AECOPD was higher in the latter group (1.579 (95% CI 1.049–2.378), p=0.029). Likewise, time to first moderate and severe AECOPD was shorter in these patients. Finally, there was no relationship between FeNO levels and circulating eosinophils.Persistent FeNO levels ≥20 ppb in clinically stable COPD outpatients are associated with a significantly higher risk of AECOPD.Persistently elevated FeNO levels in COPD are associated with a higher risk of exacerbation http://ow.ly/fdPy30hdBzo ER -