RT期刊文章SR电子T1新型磁共振技术用于囊性纤维化肺疾病的功能成像JF欧洲呼吸杂志JO EUR RESSIR J FD欧洲呼吸学会SP 1701464 DO 10.1183/13993003.01464-2017 vo 50188bet官网地址A1 Sommer，Gregor A1 Stranzinger，Enno A1 Pusterla，Orso A1 Frey，Urs A1 Korten，Insa A1歌手，Florian A1 Casaulta，Carmen A1 Bieri，Oliver A1 Latzin，Philipp yr 2017 ul //www.qdcxjkg.com/www.qdcxjkg.com/comtents.com/comtents.com/comtents.com/comtents.com/comtents.com/comtents.com/comtents.com/contents.com/contents.com/contents.com/50/6/1701464.抗肺功能测试通常用于监测囊性纤维化（CF）中的肺部疾病。虽然实用，但他们无法找到功能障碍的确切起源。当代磁共振成像（MRI）技术提供了有关疾病位置的信息，但是对对比剂的需求限制了其重复应用。我们检查了功能性MRI之间的相关性，无需施用造影剂，以及来自氮多呼吸冲洗（N2-MBW）的肺清除指数（LCI）。40名CF（中位数（范围）年龄12.0（6-18）的儿童（6-18） years) and 12 healthy age-matched controls underwent functional and structural MRI and lung function tests on the same day. Functional MRI provided semiquantitative measures of perfusion (RQ) and ventilation (RFV) impairment as percentages of affected lung volume. Morphological MRI was evaluated using CF-specific scores. LCI measured global ventilation inhomogeneity.MRI detected functional impairment in CF: RFV 19–38% and RQ 16–35%. RFV and RQ correlated strongly with LCI (r=0.76, p<0.0001 and r=0.85, p<0.0001, respectively), as did total morphology score (r=0.81, p<0.0001). All indices differed significantly between patients with CF and healthy controls (p<0.001).Noninvasive functional MRI is a promising method to detect and visualise perfusion and ventilation impairment in CF without the need for contrast agents.New functional MRI without the need for contrast agents correlates strongly with ventilation inhomogeneity in CF http://ow.ly/emo930eQJ67