％0刊期刊文章戴维斯，Gwyneth％的股票，珍妮特％A Thia，Lena P.％A Hoo，Ah-Fong％A Bush，Andrew％A Aurora，Paul％A Brennan，Lucy％A Lee，Simon％alum，sooky％a cottam，philippa％英里，joanne％a chudleigh，简％a kirkby，jane％a balfour-lynn，伊恩m.％a carr，siobhánb.％a wallis，colin％wyatt，hilary％涉及涉水，Angie％患有标准英国护理囊性纤维化的新生儿筛查婴儿的％T肺功能缺陷是轻度和瞬态％D 2017％R 10.1183 / 13993003.00326-2017％J欧洲呼吸期轴颈％p 1700326％v 50％n5％X随着新型设计师分子的出现，用于囊性纤维化（CF）治疗，巨大需要早期临床试验结果，如婴幼儿肺功能（ILF）。我们调查了在CF新生儿筛查婴儿的前2年寿命期间的ILF异常的程度和跟踪。在0.5秒（FEV0.5）中，肺部间隙指数（LCI）和血液测量功能残留能力在〜3中测量了〜3 months, 1 year and 2 years in 62 infants with CF and 34 controls.By 2 years there was no significant difference in FEV0.5 z-score between CF and controls, whereas mean LCI z-score was 0.81 (95% CI 0.45–1.17) higher in CF. However, there was no significant association between LCI z-score at 2 years with either 3-month or 1-year results. Despite minimal average group changes in any ILF outcome during the second year of life, marked within-subject changes occurred. No child had abnormal LCI or FEV0.5 on all test occasions, precluding the ability to identify “high-risk” infants in early life.In conclusion, changes in lung function are mild and transient during the first 2 years of life in newborn screened infants with CF when managed according to a standardised UK treatment protocol. Their potential role in tracking disease to later childhood will be ascertained by ongoing follow-up.Lung function changes in newborn screened infants with cystic fibrosis are mild and transient up to age 2 years http://ow.ly/7gkW30etHtb %U //www.qdcxjkg.com/content/erj/50/5/1700326.full.pdf