TY - T1的汽车引起的空气污染暴露在5年时间内与哮喘和肺功能不佳的风险增加在中年JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02357 -2016欧元六世- 50 - 4 SP - 1602357 AU - Gayan Bowatte AU - Bircan Erbas盟——卡罗琳·J·洛奇盟——卢克·d·Knibbs AU -莱尔·c·Gurrin盟人b标志着非盟——保罗·s·托马斯盟——大卫·p·约翰斯AU -格雷厄姆·g·贾尔斯AU -珍妮回族非盟-马丁尼Dennekamp AU -詹妮弗L. Perret AU - Michael J. Abramson AU - E. Haydn Walters AU - Melanie C. Matheson AU - Shyamali C. Dharmage Y1 - 2017/10/01 UR - //www.qdcxjkg.com/content/50/4/1602357.abstract N2 - Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene–environment interactions using longitudinal data from an established cohort study.Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathione S-transferase gene variants.Living <200 m from a major road was associated with increased prevalence of current asthma and wheeze, and lower lung function. The association between living <200 m from a major road and current asthma and wheeze was more marked for carriers of the GSTT1 null and GSTP1 val/val or ile/val genotypes. Over the 5-year period, higher NO2 exposures were associated with increased current asthma prevalence. Higher NO2 exposure was associated with lower forced vital capacity for carriers of the GSTT1 null genotype.TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with the GSTT1 genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects.TRAP is associated with increased risks of asthma and reduced lung function in middle-aged adults http://ow.ly/Yt2n30etMkS ER -