TY -的T1 SERVE-HF治疗分析:美国能源部s the on-treatment analysis SERVE its purpose? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01516-2017 VL - 50 IS - 2 SP - 1701516 AU - Bradley, T. Douglas Y1 - 2017/08/01 UR - //www.qdcxjkg.com/content/50/2/1701516.abstract N2 - The randomised clinical trial (RCT) is the best-accepted means to assess the effectiveness of a treatment for a given disease because treatment allocation is not influenced by non-random factors such as patient or physician preference. Conversely, observational trials, in which treatment allocations are not randomised, can be, and often are, subject to patient or physician preference. For this reason, the results of observational trials of various interventions are not considered to carry as much weight as those of RCTs, and results of such trials are often considered to be only suggestive or hypothesis generating, rather than definitive. Indeed, in several instances, the positive treatment results of observational trials have not been borne out by RCTs. For example, in the field of sleep apnoea and cardiovascular diseases, several non-randomised observational studies reported reduced fatal and non-fatal cardiovascular events rates among obstructive sleep apnoea (OSA) patients who elected to be treated by, and to continue on, continuous positive airway pressure (CPAP) compared to those who elected not to be treated by, or who discontinued, such treatment [1–3]. In contrast, several large-scale RCTs of treatment of OSA by CPAP demonstrated no beneficial effect of CPAP on fatal or non-fatal cardiovascular events [4–6]. Nevertheless, the reliability of the results of an RCT depends on the degree of adherence to the treatment allocation: the greater the adherence, the more reliable the results, and vice versa. For these reasons, there are various means by which RCTs can be analysed that take into account treatment adherence.Minute-ventilation triggered ASV increases mortality in heart failure patients with central sleep apnoea http://ow.ly/wIcr30dXlu7 ER -