ty-jour t1 - 支气管挑战的技术标准测试：一般考虑和甲素挑战性能测试jf - 欧洲呼吸杂志jo - 欧元reshir j do - 10.1183 / 13993003.01526-2016 vl - 49是 - 5 sp - 1601526互惠岩杰克阿鲁斯，杰克·奥克斯，唐纳德·奥尔德，乌克森，吐鲁·奥克森，祖哈兰·奥温，盖尔·奥克森，Gail Au - 大厅，Graham L.，Gruce H. Au - Cockcroft，Donald W. Au - Cullvroft。AU - Hallstrand, Teal S. AU - Horvath, Ildiko AU - de Jongh, Frans H.C. AU - Joos, Guy AU - Kaminsky, David A. AU - Laube, Beth L. AU - Leuppi, Joerg D. AU - Sterk, Peter J. Y1 - 2017/05/01 UR - //www.qdcxjkg.com/content/49/5/1601526.abstract N2 - This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. There are notable changes from prior recommendations in order to accommodate newer delivery devices. Rather than basing the test result upon a methacholine concentration (provocative concentration (PC20) causing a 20% fall in forced expiratory volume in 1 s (FEV1)), the new recommendations base the result upon the delivered dose of methacholine causing a 20% fall in FEV1 (provocative dose (PD20)). This end-point allows comparable results from different devices or protocols, thus any suitable nebuliser or dosimeter may be used, so long as the delivery characteristics are known. Inhalation may be by tidal breathing using a breath-actuated or continuous nebuliser for 1 min (or more), or by a dosimeter with a suitable breath count. Tests requiring maximal inhalations to total lung capacity are not recommended because the bronchoprotective effect of a deep breath reduces the sensitivity of the test.The new ERS recommendation for methacholine challenge tests will be the provocative dose rather than concentration http://ow.ly/FBe5309yXn2 ER -