TY -的T1 -端粒长度,慢性阻塞性肺病和肺气肿as risk factors for lung cancer JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01521-2016 VL - 49 IS - 1 SP - 1601521 AU - de-Torres, Juan P. AU - Sanchez-Salcedo, Pablo AU - Bastarrika, Gorka AU - Alcaide, Ana B. AU - Pío, Rubén AU - Pajares, María Jose AU - Campo, Arantza AU - Berto, Juan AU - Montuenga, Luis AU - del Mar Ocon, Maria AU - Monente, Carmen AU - Celli, Bartolome R. AU - Zulueta, Javier J. Y1 - 2017/01/01 UR - //www.qdcxjkg.com/content/49/1/1601521.abstract N2 - Telomeres are DNA–protein structures that protect chromosome ends from degradation and shorten progressively with each cell division [1].Telomere length measured in peripheral leukocytes has been used to determine an individual's “biological age”, and previous reports have demonstrated that patients with chronic obstructive pulmonary disease (COPD) and/or emphysema have shorter peripheral leukocyte telomere length [2–5]. The presence of COPD and emphysema are independent risk factors for the ultimate development of lung cancer [6, 7].Leukocyte telomere length should be included among the independent risk factors associated with lung cancer http://ow.ly/uzlg304Qpn6J.P. de-Torres, G. Bastarrika, J.J. Zulueta, P. Sanchez-Salcedo, B.R. Celli (conception and design, analysis and interpretation, and drafting the manuscript for important intellectual content); A.B. Alcaide, J. Berto, A. Campo, M. del Mar Ocon, C. Monente, R. Pío, M.J. Pajares, L. Montuenga (analysis and interpretation). ER -