@article {ChuPA2756, author = {Chu, Haiqing and Li, Bing and Huang, Dongdong and Zhang, Zhemin and Zhang, Jingbo and Gui, Tao and Xu, Liyun and Zhao, Lan}， title ={上海脓肿分枝杆菌亚型鉴定:药敏、细菌流行及临床表现}，体积={48}，数= {sup60}， location-id = {PA2756}， year = {2016}， doi = {10.1183/13993003.congress-2016。目的:了解上海市脓肿分枝杆菌的流行特征。188bet官网地址方法:从55例脓肿性肺疾病患者中分离出55株菌株。采用微量肉汤稀释法测定药物敏感性。通过DNA测序鉴定脓肿分枝杆菌的亚型。MLST、MST和PFGE分析序列类型(ST)和克隆复合物(CC)。通过CT检查评估临床表现。结果:鉴定出42株A型、11株M型和2株b型。A和M对替加环素和阿米卡星高度敏感(976 ~ 100\%)。a型很容易对克拉霉素产生耐药性。两种类型均对磺胺类、莫西沙星、强力霉素、亚胺培南和妥布霉素高度耐药。 MLST analysis identified 41 STs including 32 new STs. The MST algorithm distributed 55 isolates into 12 separate CC. The PFGE analysis exhibited 53 distinct restriction patterns and the M-type was closely clustered according to their ST and CC numbers. CT imaging showed that tree-in-bud pattern and patchy shadow were commonly observed in M-type, whereas pulmonary cavities were often found in A-type infection patients (P \< 0.001). Conclusions: ST1 in A and ST23 in M-type were the main epidemic strains in Shanghai. The M-type appeared to be prone to epidemic nosocomial transmission.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/48/suppl_60/PA2756}, eprint = {//www.qdcxjkg.com/content}, journal = {European Respiratory Journal} }