@article {Taranto-Montemurro1340作者= {Luigi Taranto-Montemurro斯科特·a·沙和布拉德利·a·爱德华兹阿里Azarbarzin和梅拉尼亚使用品牌和卡米拉·德·梅洛和丹尼·j·埃克特和大卫·p·白和安德鲁Wellman}, title ={去郁敏改善上呼吸道崩散性,降低阻塞性睡眠呼吸暂停综合症患者的严重程度最小的肌肉补偿},体积={48}={5},页面= {1340 - 1350}= {2016},doi ={10.1183/13993003.00823 -2016},出版商={欧洲呼吸学会},文摘={我们最近证明去郁敏减少上呼吸道扩张器的睡眠相关损失在健康人体内肌肉活动,降低咽崩散性阻塞性睡眠呼吸暂停(OSA)。188bet官网地址目前的生理研究的目的是确定的影响去郁敏上呼吸道折叠和呼吸暂停{\ textendash}呼吸不足指数(AHI)阻塞性睡眠呼吸暂停综合症的病人。安慰剂对照、双盲、随机交叉试验14阻塞性睡眠呼吸暂停综合症的病人。参与者接受治疗或安慰剂睡前以随机顺序。咽崩散性(临界坍塌压力的上呼吸道(Pcrit))和通风两种被动(V 0,被动)和活动(V 0,活跃)上呼吸道肌肉条件进行评估与持续气道正压(CPAP)操作。你好CPAP被量化了。去郁敏减少活动Pcrit(中位数(四分位范围)-5.2 (4.3)cmH2O去郁敏和-1.9 (2.7)cmH2O安慰剂;p = 0.049)但不是被动Pcrit(-2.2(3.4)和-0.7 (2.1)cmH2O;p = 0.135)。更大的减少AHI发生在那些最小的肌肉补偿(定义为V的0,active-V 0,被动)在安慰剂(r = 0.71, p = 0.009)。减少AHI的改善是由肌肉补偿(r = 0.72, p = 0.009)。In OSA patients, noradrenergic stimulation with desipramine improves pharyngeal collapsibility and may be an effective treatment in patients with minimal upper airway muscle compensation.Desipramine administered before sleep reduces pharyngeal collapsibility in patients with obstructive sleep apnoea http://ow.ly/1auA302CL8F}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/48/5/1340}, eprint = {//www.qdcxjkg.com/content/48/5/1340.full.pdf}, journal = {European Respiratory Journal} }