RT期刊文章SR电子attenuati T1高on areas on chest computed tomography in community-dwelling adults: the MESA study JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1442 OP 1452 DO 10.1183/13993003.00129-2016 VO 48 IS 5 A1 Podolanczuk, Anna J. A1 Oelsner, Elizabeth C. A1 Barr, R. Graham A1 Hoffman, Eric A. A1 Armstrong, Hilary F. A1 Austin, John H.M. A1 Basner, Robert C. A1 Bartels, Matthew N. A1 Christie, Jason D. A1 Enright, Paul L. A1 Gochuico, Bernadette R. A1 Hinckley Stukovsky, Karen A1 Kaufman, Joel D. A1 Hrudaya Nath, P. A1 Newell, John D. A1 Palmer, Scott M. A1 Rabinowitz, Dan A1 Raghu, Ganesh A1 Sell, Jessica L. A1 Sieren, Jered A1 Sonavane, Sushil K. A1 Tracy, Russell P. A1 Watts, Jubal R. A1 Williams, Kayleen A1 Kawut, Steven M. A1 Lederer, David J. YR 2016 UL //www.qdcxjkg.com/content/48/5/1442.abstract AB Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography (CT) detects lung injury, inflammation and extracellular matrix remodelling in community-dwelling adults sampled without regard to respiratory symptoms or smoking.We measured high attenuation areas (HAA; percentage of lung voxels between −600 and −250 Hounsfield Units) on cardiac CT scans of adults enrolled in the Multi-Ethnic Study of Atherosclerosis.HAA was associated with higher serum matrix metalloproteinase-7 (mean adjusted difference 6.3% per HAA doubling, 95% CI 1.3–11.5), higher interleukin-6 (mean adjusted difference 8.8%, 95% CI 4.8–13.0), lower forced vital capacity (FVC) (mean adjusted difference −82 mL, 95% CI −119–−44), lower 6-min walk distance (mean adjusted difference −40 m, 95% CI −1–−80), higher odds of interstitial lung abnormalities at 9.5 years (adjusted OR 1.95, 95% CI 1.43–2.65), and higher all cause-mortality rate over 12.2 years (HR 1.58, 95% CI 1.39–1.79).High attenuation areas are associated with biomarkers of inflammation and extracellular matrix remodelling, reduced lung function, interstitial lung abnormalities, and a higher risk of death among community-dwelling adults.Increased lung attenuation on CT may identify subclinical lung injury and inflammation in community-dwelling adults http://ow.ly/97k3300tvKX