% 0期刊文章% Podolanczuk,安娜·j . %伍ner, Elizabeth C. %A Barr, R. Graham %A Hoffman, Eric A. %A Armstrong, Hilary F. %A Austin, John H.M. %A Basner, Robert C. %A Bartels, Matthew N. %A Christie, Jason D. %A Enright, Paul L. %A Gochuico, Bernadette R. %A Hinckley Stukovsky, Karen %A Kaufman, Joel D. %A Hrudaya Nath, P. %A Newell, John D. %A Palmer, Scott M. %A Rabinowitz, Dan %A Raghu, Ganesh %A Sell, Jessica L. %A Sieren, Jered %A Sonavane, Sushil K. %A Tracy, Russell P. %A Watts, Jubal R. %A Williams, Kayleen %A Kawut, Steven M. %A Lederer, David J. %T High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study %D 2016 %R 10.1183/13993003.00129-2016 %J European Respiratory Journal %P 1442-1452 %V 48 %N 5 %X Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography (CT) detects lung injury, inflammation and extracellular matrix remodelling in community-dwelling adults sampled without regard to respiratory symptoms or smoking.We measured high attenuation areas (HAA; percentage of lung voxels between −600 and −250 Hounsfield Units) on cardiac CT scans of adults enrolled in the Multi-Ethnic Study of Atherosclerosis.HAA was associated with higher serum matrix metalloproteinase-7 (mean adjusted difference 6.3% per HAA doubling, 95% CI 1.3–11.5), higher interleukin-6 (mean adjusted difference 8.8%, 95% CI 4.8–13.0), lower forced vital capacity (FVC) (mean adjusted difference −82 mL, 95% CI −119–−44), lower 6-min walk distance (mean adjusted difference −40 m, 95% CI −1–−80), higher odds of interstitial lung abnormalities at 9.5 years (adjusted OR 1.95, 95% CI 1.43–2.65), and higher all cause-mortality rate over 12.2 years (HR 1.58, 95% CI 1.39–1.79).High attenuation areas are associated with biomarkers of inflammation and extracellular matrix remodelling, reduced lung function, interstitial lung abnormalities, and a higher risk of death among community-dwelling adults.Increased lung attenuation on CT may identify subclinical lung injury and inflammation in community-dwelling adults http://ow.ly/97k3300tvKX %U //www.qdcxjkg.com/content/erj/48/5/1442.full.pdf