TY -的T1高衰减地区胸部computed tomography in community-dwelling adults: the MESA study JF - European Respiratory Journal JO - Eur Respir J SP - 1442 LP - 1452 DO - 10.1183/13993003.00129-2016 VL - 48 IS - 5 AU - Podolanczuk, Anna J. AU - Oelsner, Elizabeth C. AU - Barr, R. Graham AU - Hoffman, Eric A. AU - Armstrong, Hilary F. AU - Austin, John H.M. AU - Basner, Robert C. AU - Bartels, Matthew N. AU - Christie, Jason D. AU - Enright, Paul L. AU - Gochuico, Bernadette R. AU - Hinckley Stukovsky, Karen AU - Kaufman, Joel D. AU - Hrudaya Nath, P. AU - Newell, John D. AU - Palmer, Scott M. AU - Rabinowitz, Dan AU - Raghu, Ganesh AU - Sell, Jessica L. AU - Sieren, Jered AU - Sonavane, Sushil K. AU - Tracy, Russell P. AU - Watts, Jubal R. AU - Williams, Kayleen AU - Kawut, Steven M. AU - Lederer, David J. Y1 - 2016/11/01 UR - //www.qdcxjkg.com/content/48/5/1442.abstract N2 - Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography (CT) detects lung injury, inflammation and extracellular matrix remodelling in community-dwelling adults sampled without regard to respiratory symptoms or smoking.We measured high attenuation areas (HAA; percentage of lung voxels between −600 and −250 Hounsfield Units) on cardiac CT scans of adults enrolled in the Multi-Ethnic Study of Atherosclerosis.HAA was associated with higher serum matrix metalloproteinase-7 (mean adjusted difference 6.3% per HAA doubling, 95% CI 1.3–11.5), higher interleukin-6 (mean adjusted difference 8.8%, 95% CI 4.8–13.0), lower forced vital capacity (FVC) (mean adjusted difference −82 mL, 95% CI −119–−44), lower 6-min walk distance (mean adjusted difference −40 m, 95% CI −1–−80), higher odds of interstitial lung abnormalities at 9.5 years (adjusted OR 1.95, 95% CI 1.43–2.65), and higher all cause-mortality rate over 12.2 years (HR 1.58, 95% CI 1.39–1.79).High attenuation areas are associated with biomarkers of inflammation and extracellular matrix remodelling, reduced lung function, interstitial lung abnormalities, and a higher risk of death among community-dwelling adults.Increased lung attenuation on CT may identify subclinical lung injury and inflammation in community-dwelling adults http://ow.ly/97k3300tvKX ER -