TY - JOUR T1 -性别和年龄对OSA共病负担的影响:来自美国大型全国性健康索赔数据库JF -欧洲呼吸杂志JO - Eur Respir J SP - 1162 LP - 1169 DO - 10.1183/13993003.01618-2015 VL - 47 IS - 4 AU - Mokhlesi, Babak AU - Ham, Sandra a . AU - Gozal，David Y1 - 2016/04/01 UR - //www.qdcxjkg.com/content/47/4/1162.abstract N2 -阻塞性睡眠呼吸暂停(OSA)是一种非常普遍的疾病，但由于样本量小，女性代表性不足，探索OSA相关共病负担的研究受到限制。我们查询了Truven健康市场扫描研究数据库2003-2012，这是一个健康保险索赔的工作成年人和退休人员与雇主赞助的健康保险的集合。从OSA诊断指数日起随访至少12个月且具有OSA诊断代码的成年人与匹配的随机样本进行比较。合并症采用国际疾病分类第九版代码进行评估。建立logistic回归模型检验OSA与合并症之间的独立相关性。我们的队列包括1 704 905例OSA患者和1 704 417例匹配对照。所有合并症在OSA患者中明显更为普遍。2型糖尿病和缺血性心脏病在男性中更普遍，但高血压和抑郁症在患有阻塞性睡眠呼吸暂停(OSA)的女性中更普遍。相比之下，充血性心力衰竭、心律失常和中风患病率的性别差异则不那么明显。共病的患病率随着年龄的增长而增加，但年龄的影响因具体的共病而异。 The divergence between OSA and controls was more pronounced after the sixth decade of life for most cardiovascular diseases (i.e. heart failure, ischaemic heart disease, stroke and arrhythmias), while depression exhibited an opposite trend. In a fully adjusted model, the odds of all comorbidities were significantly increased in OSA patients.In a large, nationally representative sample of working and retired people, OSA is strongly associated with significant comorbidities in both men and women with unique sex differences emerging.OSA is associated with comorbidities in both men and women with a unique pattern of sex and age differences http://ow.ly/V4Rg6 ER -