RT期刊文章SR电子T1 MeropeNem/含克拉烯酸盐的含有效率和安全性在MDR-和XDR-TB JF欧洲呼吸道治疗中的治疗方案188bet官网地址IS 4 A1 Tiberi，Simon A1 Payen，Marie-Christine A1 Sotgiu，Giovanni A1 D'Ambrosio，Lia A1 Alarcon Guizado，Valentina A1 Alffenaar，Jan Willem A1 Abdo Arbe，Marcos A1 Caminero，Jose A.A1 Caminero，Jose A. A1 Centis，Jose A.A1 Centis，Rosella a1 de lorrerele a1 de lororele a1 de lororen a1 loreren a1 loreren a1, Saverio A1 Gaga, Mina A1 Gualano, Gina A1 Roby Arias, Aurora Jazmín A1 Scardigli, Anna A1 Skrahina, Alena A1 Solovic, Ivan A1 Sulis, Giorgia A1 Tadolini, Marina A1 Akkerman, Onno W. A1 Alarcon Arrascue, Edith A1 Aleska,Alena A1 Avchinko, Vera A1 Bonini, Eduardo Henrique A1 Chong Marín, Félix Antonio A1 Collahuazo López, Lorena A1 de Vries, Gerard A1 Dore, Simone A1 Kunst, Heinke A1 Matteelli, Alberto A1 Moschos, Charalampos A1 Palmieri, Fabrizio A1 Papavasileiou, ApostolosA1 Spanevello，Antonio A1 VArgas Vasquez，Dante A1 Viggiani，Pietro A1 White，Veronica A1 Zumla，Alimuddin A1 Migliori，Giovanni Battista Yr 2016 Ul //www.qdcxjkg.com/content.com/content/content/content/47/47/47/4/1235.bssctalMeropenem/Clavulanate对多药和广泛耐药性结核病（MDR-和XDR-TB）的功效，安全性和耐受性。这项观察性研究的目的是评估Meropenem/clavulanate的治疗贡献，有效性，安全性和耐受性概况在处理MDR-和XDR-TB病例时添加到背景方案中。= 96）表现出比暴露于MeropeNem/Clavulanate-Sparanate Sparing方案（n = 168）的耐药性特征更大：在前组中，XDR-TB更频繁（49％对6.0％，P <0.0001）和中位数（四分位数范围（IQR））抗生素抗性数量较高（8（6-9）对5（4-6））。患者接受了含有梅罗培酸/克拉烯酸酯的治疗方案的中位数（IQR）为85（49-156）天。在整个MDR-TB队列中，没有统计学上的显着差异，并且在带有和没有XDR-TB的亚组中。 patients; in particular, sputum smear and culture conversion rates were similar in XDR-TB patients exposed to meropenem/clavulanate-containing regimens (88.0% versus 100.0%, p=1.00 and 88.0% versus 100.0%, p=1.00, respectively). Only six cases reported adverse events attributable to meropenem/clavulanate (four of them then restarting treatment).The nondifferent outcomes and bacteriological conversion rate observed in cases who were more severe than controls might imply that meropenem/clavulanate could be active in treating MDR- and XDR-TB cases.Meropenem/clavulanate is effective and safe to treat MDR- and XDR-TB in comparison with controls http://ow.ly/XG75j