@Article {Tiberi1235，作者= {Tiberi，Simon和Payen，Marie-Christine和Sotgiu，Giovanni和D {\ TextQuoteright} Ambrosio，Lia和Alarcon Guizado，Valentina，Valentina，Valentina和Alffena，Jan Willem和Abdo Arbex，Marcos和Camcos和Camcos和Camcos和Jose，Jose，Jose，Jose和Camcos，Jose，Jose，。Marina和Akkerman，Onno W.和Alarcon Astascue，Edith和Aleska，Alena和Avchinko，Vera和Bonini，Eduardo Henrique和Chong Mar {\'\ i} n，f {\'e}o}pez, Lorena and de Vries, Gerard and Dore, Simone and Kunst, Heinke and Matteelli, Alberto and Moschos, Charalampos and Palmieri, Fabrizio and Papavasileiou, Apostolos and Spanevello, Antonio and Vargas Vasquez, Dante and Viggiani, Pietro and White,Veronica和Zumla，Alimuddin和Migliori，Giovanni Battista}，title = {Meropenem/clavulanate-containi的有效性和安全性NG治疗中的NG方案MDR-和XDR-TB}，音量= {47}，number = {4}，pages = {1235---1243}，年= {2016}，doi = {10.1183/139993003.02146-2015}，出版商= {欧洲呼吸社会}，188bet官网地址Abstract = {没有大型研究评估了Meropenem/Clavulanate对治疗多药和广泛耐药性结核病（MDR-和XDR-TB）的功效，安全性和耐受性。这项观察性研究的目的是评估Meropenem/clavulanate的治疗贡献，有效性，安全性和耐受性概况在处理MDR-和XDR-TB病例时添加到背景方案中。= 96）表现出比暴露于MeropeNem/Clavulanate-Sparanate Sparing方案的耐药性概况更大（n = 168）：在前一个组中，XDR-TB更频繁（49 \％\％v vers 6.0 \％，p \ <0.0001）抗生素电阻的中位数（四分位数范围（IQR））较高（8（6 {\ textendash} 9），对5（4 {\ textendendash} 6）。患者接受了含有梅罗培农/克拉烯酸酯的方案治疗，中位（IQR）为85（49 {\ textendash} 156）天。XDR-TB患者； in particular, sputum smear and culture conversion rates were similar in XDR-TB patients exposed to meropenem/clavulanate-containing regimens (88.0\% versus 100.0\%, p=1.00 and 88.0\% versus 100.0\%, p=1.00, respectively). Only six cases reported adverse events attributable to meropenem/clavulanate (four of them then restarting treatment).The nondifferent outcomes and bacteriological conversion rate observed in cases who were more severe than controls might imply that meropenem/clavulanate could be active in treating MDR- and XDR-TB cases.Meropenem/clavulanate is effective and safe to treat MDR- and XDR-TB in comparison with controls http://ow.ly/XG75j}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/47/4/1235}, eprint = {//www.qdcxjkg.com/content/47/4/1235.full.pdf}, journal = {European Respiratory Journal} }