TY - T1的敏感性C-Tb:小说RD-1-specific skin test for the diagnosis of tuberculosis infection JF - European Respiratory Journal JO - Eur Respir J SP - 919 LP - 928 DO - 10.1183/13993003.01464-2015 VL - 47 IS - 3 AU - Hoff, Soren T. AU - Peter, Jonathan G. AU - Theron, Grant AU - Pascoe, Mellissa AU - Tingskov, Pernille N. AU - Aggerbeck, Henrik AU - Kolbus, Daniel AU - Ruhwald, Morten AU - Andersen, Peter AU - Dheda, Keertan Y1 - 2016/03/01 UR - //www.qdcxjkg.com/content/47/3/919.abstract N2 - C-Tb, a novel Mycobacterium tuberculosis and 6-kDa early secretory antigenic target/10-kDa culture filtrate protein (ESAT-6/CFP-10)-specific skin test, has high specificity in bacille Calmette–Guerin-vaccinated healthy controls. However, the sensitivity of C-Tb has hitherto not been determined. The objective was to determine the sensitivity of C-Tb in patients with active tuberculosis (TB) in comparison with the tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFT-GIT).C-Tb and TST were randomly administered in a double-blinded fashion to one or the other forearm in 253 patients with active TB with or without HIV co-infection. QFT-GIT testing was performed prior to skin testing.Using a receiver operating characteristic curve-derived cut-point of 5 mm, C-Tb sensitivity was similar to QFT-GIT (73.9 (95% CI 67.8–79.3) versus 75.1 (95% CI 69.3–80.2)), and similar in HIV-infected and HIV-uninfected patients (76.7 (95% CI 69.0–83.3) versus 69.5 (95% CI 59.2–78.5)). However, sensitivity was significantly diminished in HIV-infected patients with CD4 counts <100 cells·mm–3. C-Tb and QFT-GIT combined had significantly higher sensitivity than C-Tb alone (p<0.0001). C-Tb was safe with no significant adverse events. The 5 mm cut-point corresponded to that found in the previously published specificity study (TESEC-04).C-Tb has similar sensitivity compared with QFT-GIT for the diagnosis of M. tuberculosis infection. Sensitivity was reduced only in HIV-infected patients with severe immunosuppression. Further studies in different settings are required to validate the proposed 5 mm cut-point.C-Tb has similar sensitivity compared with QFT-GIT for the diagnosis of M. tuberculosis infection http://ow.ly/TtFf6 ER -