TY - T1的建议影响预后的相关分级方案肺鳞状细胞癌JF -欧洲呼吸杂志》乔和J SP - 938 LP - 946欧元——10.1183/13993003.00937 -2015六世- 47 - 3盟Wilko Weichert盟克劳迪娅Kossakowski AU -亚历山大危害盟彼得·亨德里克•Dienemann Schirmacher AU -托马斯·莫利盟盟——Arne带有愤怒Y1 - 2016/03/01 UR - //www.qdcxjkg.com/content/47/3/938.abstract N2 -在肺腺癌建立了最近的研究clinically relevant histomorphology-based classification. In contrast, no morphological classifiers have yet been implemented into routine diagnostics for lung squamous cell carcinoma (SQCC). However, morphology-based characteristics putatively impacting on survival have been proposed.We analysed a cohort of 541 SQCC patients with complete clinical follow-up data for morphological characteristics (keratinisation, tumour cell budding, size of tumour cell nests, nuclear size and stromal content). Morphological characteristics were correlated with clinical data and patient outcome.Keratinisation, budding, stromal content and tumour cell nest size, but not nuclear size, were associated with distinct clinicopathological characteristics and survival. SQCC patients with keratinisation, small cell nest size, high stromal content and extensive budding had shorter overall survival. A combined grading scheme composed of the two most reliable validated prognostic markers, i.e. budding and nest size, resulted in an age-, stage- and sex-independent prognosticator for overall survival with a hazard ratio of 1.6 for grade 2 tumours and a hazard ratio of 3.7 for grade 3 tumours when compared with grade 1 neoplasms (p<0.001).Morphological characteristics of SQCC have significant prognostic impact and could constitute the basis for a diagnostically relevant future SQCC grading scheme.Morphological characteristics of pulmonary squamous cell carcinoma have significant prognostic impact for survival http://ow.ly/St6mM ER -