@Article {derks615，作者= {derks，Jules L.和Hendriks，Lizza E.和Buikhuisen，Wieneke A.和Groen，Harry J.M.和Thunnissen，Erik和Van Suylen，and Robert-Jan和Robert-Jan和Roud and roud and ruud and ruud and ruud and ruud and ruud and damhuis，and ruud and ronald。-624}，Year = {2016}，doi = {10.1183/13993003.00618-2015}，Publisher = {欧洲呼吸188bet官网地址社会}，摘要= {肺大细胞神经内泌癌（LCNEC）是孤儿疾病的，较少有数据它的临床特征。因此，我们分析了在荷兰癌症注册中注册的LCNEC，并将数据与小细胞肺癌（SCLC），鳞状细胞癌（SQCC）和腺癌（ADC）进行了比较。组织学确认的LCNEC（n = 952），SCLC（n = 11），SCLC（n = 11 844), SqCC (n=19 633) and AdC (n=24 253) cases were selected from the Netherlands Cancer Registry (2003{\textendash}2012). Patient characteristics, metastasis at diagnosis (2006 or later), overall survival (OS) including multivariate Cox models and first-line treatment were compared for stage I{\textendash}II, III and IV disease.The number of LCNEC cases increased from 56 patients in 2003 to 143 in 2012, accounting for 0.9\% of all lung cancers. Stage IV LCNEC patients (n=383) commonly had metastasis in the liver (47\%), bone (32\%) and brain (23\%), resembling SCLC. Median OS (95\% CI) of stage I{\textendash}II, III and IV LCNEC patients was 32.4 (22.0{\textendash}42.9), 12.6 (10.3{\textendash}15.0) and 4.0 (3.5{\textendash}4.6) months, respectively. Multivariate-adjusted OS of LCNEC patients resembled that of SCLC patients, and was poorer than those of SqCC and AdC patients. However, frequency of surgical resection and adjuvant chemotherapy resembled SqCC and AdC more than SCLC.Diagnosis of LCNEC has increased in recent years. The metastatic pattern of LCNEC resembles SCLC as does the OS. However, early-stage treatment strategies seem more comparable to those of SqCC and AdC.Outcome of LCNEC is poor and metastatic pattern resembles SCLC, yet stage I{\textendash}II treatment corresponds more with NSCLC http://ow.ly/S37N9}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/47/2/615}, eprint = {//www.qdcxjkg.com/content/47/2/615.full.pdf}, journal = {European Respiratory Journal} }