TY - T1的维生素D压制鼻病毒replication in cystic fibrosis cells by inducing LL-37 JF - European Respiratory Journal JO - Eur Respir J SP - 520 LP - 530 DO - 10.1183/13993003.00665-2015 VL - 47 IS - 2 AU - Schögler, Aline AU - Muster, Ricardo J. AU - Kieninger, Elisabeth AU - Casaulta, Carmen AU - Tapparel, Caroline AU - Jung, Andreas AU - Moeller, Alexander AU - Geiser, Thomas AU - Regamey, Nicolas AU - Alves, Marco P. Y1 - 2016/02/01 UR - //www.qdcxjkg.com/content/47/2/520.abstract N2 - Vitamin D has immunomodulatory properties in the defence against pathogens. Its insufficiency is a widespread feature of cystic fibrosis (CF) patients, which are repeatedly suffering from rhinovirus (RV)-induced pulmonary exacerbations.To investigate whether vitamin D has antiviral activity, primary bronchial epithelial cells from CF children were pre-treated with vitamin D and infected with RV16. Antiviral and anti-inflammatory activity of vitamin D was assessed. RV and LL-37 levels were measured in bronchoalveolar lavage (BAL) of CF children infected with RV.Vitamin D reduced RV16 load in a dose-dependent manner in CF cells (10−7 M, p<0.01). The antiviral response mediated by interferons remained unchanged by vitamin D in CF cells. Vitamin D did not exert anti-inflammatory properties in RV-infected CF cells. Vitamin D increased the expression of the antimicrobial peptide LL-37 up to 17.4-fold (p<0.05). Addition of exogenous LL-37 decreased viral replication by 4.4-fold in CF cells (p<0.05). An inverse correlation between viral load and LL-37 levels in CF BAL (r=−0.48, p<0.05) was observed.RV replication in primary CF bronchial cells was reduced by vitamin D through the induction of LL-37. Clinical studies are needed to determine the importance of an adequate control of vitamin D for prevention of virus-induced pulmonary CF exacerbations.Rhinovirus replication is decreased in CF cells by vitamin D through the induction of the antimicrobial peptide LL-37 http://ow.ly/Snsyo ER -